基于熵权TOPSIS法的药学干预对鸦胆子油乳 注射液 合理应用的影响  

Effects of Pharmacological Intervention Based on Entropy-Weighted TOPSIS Method on the Rational Application of Brucea Javanica Oil Emulsion Injection

作　　者：周萌萌 徐海军 马鑫 李思光 王苗苗 王纪伟 姚威 唐长征 ZHOU Mengmeng;XU Haijun;MA Xin;LI Siguang;WANG Miaomiao;WANG Jiwei;YAO Wei;TANG Changzheng(Dept.of Pharmacy,Bozhou Hospital of Traditional Chinese Medicine,Anhui Bozhou 236800,China;Dept.of Oncology,Bozhou Hospital of Traditional Chinese Medicine,Anhui Bozhou 236800,China;Dept.of Pharmacy,Jinan Hospital of Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Traditional Chinese medicine,Jinan 250012,China)

机构地区：[1]亳州市中医院药学部,安徽亳州236800 [2]亳州市中医院肿瘤科,安徽亳州236800 [3]中国中医科学院广安门医院济南医院药学部,济南250012

出　　处：《中国医院用药评价与分析》2025年第4期498-501,507,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：亳州市重点研发计划项目(No.bzzc2024076)。

摘　　要：目的:探讨基于熵权逼近理想解排序法(TOPSIS)的药学干预对鸦胆子油乳注射液合理应用的影响,为临床合理用药提供依据。方法:参照药品说明书、相关书籍、指南制定评价标准草案,经向专家咨询,最终拟定鸦胆子油乳注射液合理应用评价标准。抽取干预前(2022年1-6月)、干预后(2022年7-12月)亳州市中医院使用鸦胆子油乳注射液的出院病历资料,分别为161、118份。利用熵权TOPSIS法对鸦胆子油乳注射液归档病历进行评价,计算每份病历与最优解的相对接近度(C i),C i≥80%为用药合理,C i在60%~<80%为基本用药合理,Ci<60%为用药不合理。运用χ2检验对干预前后的用药合理率进行对比分析。结果:干预前的161份病历中,10份病历的C i≥80%,52份病历的C i在60%~<80%,99份病历的C i<60%。干预后的118份病历中,45份病历的C i≥80%,49份病历的C i在60%~<80%,24份病历的C i<60%。与干预前比较,干预后在适应证、给药频次、给药浓度、用药疗程方面的合理率更高,差异均有统计学意义(P<0.05)。结论:基于熵权TOPSIS法的药学干预可促进鸦胆子油乳注射液的临床合理应用。OBJECTIVE:To explore the effects of pharmaceutical intervention on rational use of Brucea javanica oil emulsion injection based on the entropy-weighted technique for order preference by similarity to ideal solution(TOPSIS)method.METHODS:According to drug instructions,related books and guidelines,the draft of the evaluation standard was formulated,and the evaluation standard for the rational application of Brucea javanica oil emulsion injection was finally formulated by consulting experts.Discharged medical records with Brucea javanica oil emulsion injection in Bozhou Hospital of Traditional Chinese Medicine before the intervention(161 cases,from Jan.to Jun.2022)and after the intervention(118 cases,from Jul.to Dec.2022)were collected.The entropy-weight TOPSIS method was used to evaluate the archived medical records of Brucea javanica oil emulsion injection.The relative proximity(C i)between each medical record and the optimal solution was calculated.C i≥80%was considered as rational drug use,60%to<80%was considered as rational basic drug use,and<60%was considered as irrational drug use.χ2 test was used to compare and analyze the rational rate of medication before and after intervention.RESULTS:Of 161 medical records before intervention,10 medical records had C i≥80%,52 medical records had C i between 60%and<80%,and 99 cases had C i<60%.Of the 118 medical records after intervention,45 cases had C i≥80%,49 cases had C i between 60%and<80%,and 24 cases had C i<60%.Compared with before intervention,the rational rate of indications,frequency of administration,concentration of medication and duration of medication were higher after intervention,and the differences were statistically significant(P<0.05).CONCLUSIONS:The entropy-weighted TOPSIS pharmaceutical intervention can promote the rational use of Brucea javanica oil emulsion injection and ensure the medication safety.

关 键 词：鸦胆子油乳注射液 药学干预 逼近理想解排序法 合理用药 药物利用评价 

分 类 号：R969.3[医药卫生—药理学] R979.1[医药卫生—药学]