纳米级药物载体的制备及其抗癌、抗菌应用新进展  

Recent Advances in the Preparation of Nanoscale Drug Carriers and Their Applications in Anticancer and Antimicrobial Therapies

作　　者：赵晨彤 陈静怡 张伟娜 翟宏菊[2] 原景玲 刘姝彤 Zhao Chentong;Chen Jingyi;Zhang Weina;Zhai Hongju;Yuan Jingling;Liu Shutong(Shangqiu Medical College,Shangqiu,476000;College of Chemistry,Jilin Normal University,Siping,136000)

机构地区：[1]商丘医学高等专科学校,商丘476000 [2]吉林师范大学化学学院,四平136000

出　　处：《化学通报(中英文)》2025年第4期354-368,共15页Chemistry

基　　金：吉林省科技发展计划项目(YDZJ202401375ZYTS);吉林省发展和改革委员会项目(2024C019-4);商丘医学高等专科学校开放课题(KFKT23011);2024河南省高等学校重点科研项目(24B350009)资助。

摘　　要：近年来,纳米药物载体在医药领域正受到越来越多的关注,其独特的物理化学性质,如高表面积、可调控的尺寸和形状、多功能性等,使其在药物递送方面展现出显著优势。本文介绍了常见四种纳米级药物载体(脂质体、聚合物纳米颗粒、金属及其氧族化合物纳米颗粒和碳纳米材料)的制备方法,总结了纳米药物载体在癌症治疗、抗菌感染等领域的最新研究成果,展望了纳米药物载体的未来应用领域和发展趋势。In recent years,nano-drug carriers are receiving more and more attention in the field of medicine.Their unique physical and chemical properties,such as high surface area,adjustable size and shape,and multifunctionality,allow them showing significant advantages in drug delivery.In this paper,the preparation methods of four nano-scale drug carriers,including liposomes,polymer nanoparticles,metal and oxygen compound nanoparticles and carbon nanomaterials,are introduced.The latest research results of nano-drug carriers in the fields of cancer treatment and antibacterial infection are summarized.The future application and development trends of nano-drug carriers are prospected.

关 键 词：药物递送 脂质体 纳米颗粒 碳纳米材料 

分 类 号：R943[医药卫生—药剂学]