不同严重程度急性颅脑损伤患者血糖及TNF-α、CRP、PCT水平的变化  

Observation of Blood Glucose,TNF-α,CRP and PCT Levels in Patients with Acute Craniocerebral Injury of Different Severity

作　　者：王晓伟[1] WANG Xiaowei(the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712000)

机构地区：[1]陕西中医药大学第二附属医院,陕西咸阳712000

出　　处：《医学临床研究》2025年第4期676-679,共4页Journal of Clinical Research

摘　　要：【目的】探讨不同严重程度急性颅脑损伤(ABI)患者空腹血糖(FPG)、糖化血红蛋白(HbA1c)及肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、降钙素原(PCT)水平变化情况。【方法】选取2020年1月至2023年6月本院收治的139例ABI患者,根据入院24 h内格拉斯哥昏迷评分(GCS)将患者分为轻型组(GCS为13~15分,n=43)、中型组(GCS为9~12分,n=46)和重型组(GCS为3~8分,n=50)。同时,另选取同期在本院进行体检40例健康的志愿者为对照组。比较四组研究对象FPG、HbA1c及TNF-α、CRP、PCT水平,采用Spearman相关性分析ABI患者FPG、HbA1c、TNF-α、CRP、PCT水平与病情严重程度的相关性。【结果】对照组FPG、HbA1c低于轻型组、中型组和重型组,轻型组FPG、HbA1c低于中型组和重型组,中型组FPG、HbA1c低于重型组,差异有统计学意义(P<0.05)。对照组血清TNF-α、CRP、PCT水平低于轻型组、中型组和重型组,轻型组血清TNF-α、CRP、PCT水平低于中型组和重型组,中型组血清TNF-α、CRP、PCT水平低于重型组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,ABI患者血清FPG、HbA1c、TNF-α、CRP、PCT水平与病情严重程度均呈正相关(P<0.05)。【结论】ABI患者FPG、HbA1c、TNF-α、CRP、PCT水平显著高于健康人群,且与ABI患者病情严重程度呈正相关。【Objective】To investigate the levels of fasting blood glucose(FPG),glycosylated hemoglobin a1c(HbA1c),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and procalcitonin(PCT)in patients with acute craniocerebral injury(ABI)of different severity.【Methods】A total of 139 ABI patients admitted to our hospital from January 2020 to June 2022 were selected.According to the Glasgow coma score(GCS)within 24 hours of admission,patients were divided into the mild group(GCS of 13-15,n=43),the moderate group(GCS of 9-12,n=9)and the severe group(GCS of 3-8,n=50).At the same time period,40 healthy volunteers were selected as the control group.The differences of FPG,HbA1c,TNF-α,CRP,PCT among the four groups were compared.Spearman rank correlation analysis was used to explore the relationship of the severity of the disease with levels of FPG,HbA1c,TNF-α,CRP,and PCT in ABI patients.【Results】The levels of FPG and HbA1c in the control group were lower than those in the mild,moderate and severe groups(P<0.05);FPG and HbA1c levels in the mild group were lower than those in the moderate and severe groups(P<0.05);And FPG and HbA1c levels in the moderate group were lower than those in the severe group(P<0.05).TNF-α,CRP and PCT levels in the control group were lower than those in mild,moderate and severe groups(P<0.05);The levels of TNF-α,CRP and PCT in the mild group were lower than those in the moderate and severe group(P<0.05);And TNF-α,CRP and PCT levels in the moderate group were lower than those in the severe group(P<0.05).Spearman correlation showed that FPG,HbA1c,TNF-α,CRP,and PCT were positively correlated with the severity of ABI(P<0.05).【Conclusion】Compared to healthy people,the levels of FPG,HbA1c,TNF-α,CRP and PCT in ABI patients are elevated.And FPG,HbA1c,TNF-α,CRP and PCT levels are positively correlated with the severity of the disease,which is worthy of clinical attention.

关 键 词：颅脑损伤 急性病 血糖 肿瘤坏死因子Α C反应蛋白质 降钙素原 

分 类 号：R651.15[医药卫生—外科学]