STAT与代谢性疾病的关系  

The relationship between STAT and metabolic diseases

作　　者：贺舒靖 肖泊杉 王冰玉 王琪 齐亚娟 李爽 吴乃君 HE Shujing;XIAO Boshan;WANG Bingyu;WANG Qi;QI Yajuan;LI Shuang;WU Naijun(North China University of Science and Technology Affiliated Hospital,Tangshan 063000,China;North China University of Science and Technology,Tangshan 063200,China)

机构地区：[1]华北理工大学附属医院,唐山063000 [2]华北理工大学,唐山063200

出　　处：《生命的化学》2025年第4期571-578,共8页Chemistry of Life

基　　金：河北省中医药联合基金重点项目(H2022209087)。

摘　　要：近年来,随着2型糖尿病(type 2 diabetes,T2DM)和非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)等相关代谢性疾病患者的数量显著增长,学者们对其发病基因及发病机制的研究更加深入。信号传导和转录激活因子(signal transducers and activators of transcription,STAT)作为2型糖尿病和非酒精性脂肪肝病研究的热点基因,在代谢性疾病发生及发展过程中起着重要的作用。本文就STAT与代谢性疾病关系的研究进展作一综述。In recent years,with the significant increase in the number of patients with related metabolic diseases such as type 2 diabetes mellitus and non-alcoholic fatty liver disease,scholars have studied their pathogenic genes and pathogenesis more intensively.As hotspot genes in the study of type 2 diabetes mellitus and non-alcoholic fatty liver disease,signal transducers and activators of transcription(STAT)play an important role in the occurrence and development of metabolic diseases.This work reviews the research progress on the relationship between STAT and metabolic diseases.

关 键 词：STAT 代谢性疾病 糖尿病 非酒精性脂肪性肝病 肥胖 痛风 

分 类 号：R589[医药卫生—内分泌]