白细胞介素-36亚家族与变应性鼻炎  

Interleukin-36 subfamily and allergic rhinitis

作　　者：胡涵钰 张幼芬 于梦溪 李燕[1,2] HU Hanyu;ZHANG Youfen;YU Mengxi;LI Yan(Medical Department of Ningbo University,Ningbo 315211,China;The First Affiliated Hospital of Ningbo University,Ningbo 315201,China)

机构地区：[1]宁波大学医学部,宁波315211 [2]宁波大学附属第一医院,宁波315201

出　　处：《生命的化学》2025年第4期625-632,共8页Chemistry of Life

基　　金：浙江省医药卫生科技计划项目(2022KY1148,2023KY259,2024KY1542);。

摘　　要：变应性鼻炎(allergic rhinitis,AR)即过敏性鼻炎,是一种在机体接触过敏原后由免疫球蛋白E(immunoglobulin E,IgE)介导的过敏性呼吸道疾病,主要表现为鼻痒、打喷嚏、流鼻涕和鼻塞。白细胞介素(interleukin,IL)-36细胞因子是IL-1超家族的成员,该亚家族由IL-36α、IL-36β、IL-36γ、IL-36受体(IL-36 receptor,IL-36R)拮抗剂(IL-36 receptor antagonists,IL-36Ra)和IL-38组成。IL-36α、IL-36β和IL-36γ是促炎激动剂,可触发IL-36R信号传导。IL-36Ra可抑制IL-36R的信号传导。IL-38的生物学功能与IL-36Ra相似,能阻断IL-36R信号的激活。本文将综述IL-36亚家族的生物学特性及其在AR中的作用研究进展,为研究相关疾病的治疗靶点或药物开发提供新思路。Allergic rhinitis(AR)is an allergic respiratory disease mediated by immunoglobulin E(IgE)that occurs after the body is exposed to allergens,primarily characterized by symptoms such as nasal itching,sneezing,runny nose,and nasal congestion.Interleukin(IL)-36 cytokines are members of the IL-1 superfamily,which comprises IL-36α,IL-36β,IL-36γ,IL-36 receptor antagonists(IL-36Ra),and IL-38.IL-36α,IL-36β,and IL-36γare pro-inflammatory agonists that can trigger IL-36 receptor antagonists(IL-36Ra)signaling,while IL-36Ra can inhibit IL-36R signaling.The biological function of IL-38 is similar to that of IL-36Ra,as it can block the activation of IL-36R signaling.This work will review the biological characteristics of the IL-36subfamily and its research progress regarding its role in AR,providing new insights for targeting therapies or drugs for related illnesses.

关 键 词：变应性鼻炎 白细胞介素-36α 白细胞介素-36β 白细胞介素-36γ 白细胞介素-36Ra 白细胞介素-38 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]