Apelin在多囊卵巢综合征中的作用机制  

The mechanism of Apelin in polycystic ovary syndrome

作　　者：周建华[1] 郭英[1] 夏悦 刘虹麟 谢佳妮 王奕力 倪晓容[1] ZHOU Jianhua;GUO Ying;XIA Yue;LIU Honglin;XIE Jiani;WANG Yili;NI Xiaorong(Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《生命的化学》2025年第4期654-660,共7页Chemistry of Life

基　　金：国家自然科学基金项目(81804136);上海医学创新发展基金“未来计划”中医药科技发展项目(WL-HBMS-2021003K);上海医学创新发展基金“未来计划”传统中医技术传承项目(WLJH2022ZY-ZYY005)。

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄女性常见的一种以生殖障碍为主要表现的异质性代谢性疾病,患者常存在脂肪组织功能障碍,表现为脂肪因子的异常分泌。异常分泌的脂肪因子可通过串扰性腺轴紊乱内分泌系统影响女性生殖。脂肪因子Apelin在PCOS女性的血液、卵泡液、颗粒细胞、黄体中存在差异表达,参与调控PCOS内分泌代谢及卵泡发育,可能是PCOS有效的干预靶点。本文从PCOS的代谢及卵巢功能两方面总结了Apelin的相关功能调控及机制研究,以期为以Apelin为靶点的PCOS药物研发及进一步的机制研究提供思路和理论依据。Polycystic ovary syndrome(PCOS)is a common heterogeneous metabolic disease in women of childbearing age with reproductive disorders as the main manifestation.Patients commonly have adipose tissue dysfunction,which is manifested as abnormal secretion of adipokines.Abnormally secreted adipokines disrupt the endocrine system via crosstalk with the gonadal axis,thereby impairing female reproduction.The adipokine Apelin is differentially expressed in the blood,follicular fluid,granulosa cells and corpus luteum of women with PCOS.It participates in regulating endocrine metabolism and follicular development of PCOS,suggesting its potential as a promising therapeutic target for PCOS.This review summarizes the regulatory roles and molecular mechanisms of Apelin in PCOS metabolism and ovarian function to provide ideas and theoretical foundations for the development of PCOS drugs and further mechanism studies.

关 键 词：多囊卵巢综合征 APELIN APJ 脂肪因子 

分 类 号：R711.75[医药卫生—妇产科学]