硫氧还蛋白对慢性阻塞性肺疾病的干预作用及其机制  

The intervention effect and mechanism of thioredoxin on COPD

作　　者：季振龙 吴沛霆 陈谷风 金津 周杰栋 王金泉 陶学芳 田海 JI Zhenlong;WU Peiting;CHEN Gufeng;JIN Jin;ZHOU Jiedong;WANG Jinquan;TAO Xuefang;TIAN Hai(School of Life and Environmental Sciences,Shaoxing University,Shaoxing 312000,China;School of Medicine,Shaoxing University,Shaoxing 312000,China;Department of Respiratory Medicine,the Affiliated Hospital of Shaoxing University,Shaoxing 312000,China;Jiaozhimei Biotechnology(Shaoxing)Co.,Ltd.,Shaoxing 312000,China)

机构地区：[1]绍兴文理学院生命与环境科学学院,绍兴312000 [2]绍兴文理学院医学院,绍兴312000 [3]绍兴文理学院附属医院呼吸内科,绍兴312000 [4]酵之美生物科技(绍兴)有限责任公司,绍兴312000

出　　处：《生命的化学》2025年第4期661-670,共10页Chemistry of Life

基　　金：浙江省公益技术应用研究项目(LGF22H010004)。

摘　　要：硫氧还蛋白(thioredoxin,TRX)是一种小分子分泌型蛋白质,能通过半胱氨酸巯基可逆地形成二硫键,实现还原态和氧化态之间的转化。细胞在氧化损伤、代谢紊乱、感染、炎症、辐射等情况下合成并分泌TRX,以保护细胞免受伤害。TRX具有多种生物学功能,包括调节氧化还原平衡、抗炎和抗凋亡等。研究表明,外源性TRX在呼吸系统、消化系统及皮肤等多种炎症疾病中有显著的干预作用。本文综述了TRX对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的干预作用及其分子机制。TRX通过调节氧化还原平衡、蛋白酶平衡、抑制COPD相关信号通路和炎症细胞活化等多种途径,有效地阻止COPD的进展,且不像激素类等传统药物对免疫系统有干扰抑制等不良反应。此外,抑制巨噬细胞迁移抑制因子可改善类固醇药物的治疗效果。因此,TRX有望成为COPD的新型治疗药物。Thioredoxin(TRX)is a small secreted protein that reversibly form disulfide bonds via cysteine thiol groups,enabling the transition between reduced and oxidized states.Cells synthesize and secrete TRX in response to oxidative stress,metabolic dysregulation,infections,inflammation,and radiation,thereby protecting against cellular damage.TRX exerts multiple biological functions,including the regulation of redox balance,anti-inflammatory effects,and anti-apoptotic activity.Studies indicate that exogenous TRX exhibits significant therapeutic effects in inflammatory diseases of the respiratory,digestive,and integumentary systems.This paper reviews the intervention effects and molecular mechanisms of TRX on chronic obstructive pulmonary disease(COPD).TRX effectively halts COPD progression via multiple mechanisms,including the regulation of redox and protease balance,inhibition of COPD-related signaling pathways,and suppression of inflammatory cell activation,without the immunosuppressive side effects of corticosteroids.Moreover,TRX enhances the efficacy of corticosteroids by inhibiting the macrophage migration inhibitory factor.Therefore,TRX is expected to become a new type of therapeutic medicine for COPD.

关 键 词：硫氧还蛋白 慢性阻塞性肺疾病 干预作用 糖皮质激素抵抗 

分 类 号：R563[医药卫生—呼吸系统]