In Search of New Pharmacological Targets:Beyond Carnosine’s Antioxidant,Anti-Inflammatory,and Anti-Aggregation Activities  

作　　者：Giuseppe Carota Lucia Di Pietro Vincenzo Cardaci Anna Privitera Francesco Bellia Valentina DiPietro Giuseppe Lazzarino Barbara Tavazzi Angela Maria Amorini Giacomo Lazzarino Giuseppe Caruso 

机构地区：[1]Department of Biomedical and Biotechnological Sciences,University of Catania,Catania,95123,Italy [2]Department of Drugand Health Sciences,University of Catania,Catania,95123,Italy [3]Scuola Superioredi Catania,University of Catania,Catania,95123,Italy [4]Vita-Salute San Raffaele University,Milano,20132,Italy [5]School of Infection,Inflammation&Immunology,Department of Inflammation and Ageing,College of Medicine and Health,University of Birmingham,Birmingham,B152TT,UK [6]Departmental Faculty of Medicine,UniCamillus-Saint Camillus International University of Health Sciences,Rome,00131,Italy [7]IRCCS San Camillo Hospital,Venice,30126,Italy

出　　处：《BIOCELL》2025年第4期563-578,共16页生物细胞(英文)

摘　　要：Carnosine(β-alanyl-L-histidine)is a naturally occurring endogenous peptide widely distributed in excitable tissues,such as the heart and brain.Over the years,several beneficial effects of carnosine have been discussed well in scientific literature.In particular,this dipeptide is well-known for its antioxidant,anti-inflammatory,and anti-aggregation activities.It is of great interest in the context of numerous systemic and neurodegenerative diseases,besides performing important“side activities”such as metal chelation and pH-buffering.Despite a plethora of preclinical and clinical data supporting carnosine’s therapeutic potential,researchers are still searching for new pharmacological targets that better highlight carnosine’s overall multimodal mechanism of action and allow its disease-specific use.The aim of the present mini-review,after quickly summarizing the current knowledge of carnosine biological properties,is to pinpoint the role of some non-canonical factors/pathways positively modulated by this dipeptide,highlighting their perspective role as future pharmacological targets.

关 键 词：CARNOSINE pharmacological targets nitric oxide TGF-β1 FRACTALKINE insulin-degrading enzyme N-METHYLTRANSFERASE energy metabolism 

分 类 号：R965[医药卫生—药理学]