糖尿病与左心耳功能和血栓形成相关的研究进展  

Research Progress on the Association Between Diabetes Mellitus and Left Atrial Appendage Function and Thrombosis

作　　者：孟旭阳 汪芳[1,2] MENG Xuyang;WANG Fang(Department of Cardiovascular Medicine,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Graduate School of Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100010,China)

机构地区：[1]北京医院心血管内科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730 [2]中国医学科学院,北京协和医学院研究生院,北京100010

出　　处：《中国循环杂志》2025年第4期402-405,共4页Chinese Circulation Journal

基　　金：国家重点研发计划资助项目(2020YFC2008106);中央高水平医院临床科研业务费(BJ-2022-117、BJ-2023-170、BJ-2024-180)。

摘　　要：左心耳是心房颤动(房颤)患者血栓形成的最常见部位,左心耳血栓一旦脱落会引起脑卒中、体循环栓塞等严重并发症。糖尿病不仅是房颤的独立危险因素,还促进了房颤患者左心耳功能受损和血栓形成。本文综述了糖尿病与左心耳功能和血栓形成相关的研究,初步探索潜在机制,旨在寻找可靠的评价和预测指标以及有效的治疗靶点。Left atrial appendage is the most common site of thrombosis in patients with atrial fibrillation.Once the left atrial appendage thrombosis falls off,it will cause serious complications such as stroke and systemic embolism.Diabetes is not only an independent risk factor for atrial fibrillation,but also promotes left atrial appendicular dysfunction and thrombosis in patients with atrial fibrillation.In this article,we reviewed studies on left atrial appendicular function and thrombosis in the setting of diabetes by focusing the underlying mechanisms in order to define reliable evaluation and predictive indicators,as well as effective therapeutic targets.

关 键 词：左心耳 左心耳重构 左心耳功能 左心耳血栓 糖尿病 

分 类 号：R54[医药卫生—心血管疾病]