实脾饮加减联合西医疗法治疗脾肾阳虚型肾病综合征的临床观察  

Clinical Observation on the Treatment of Nephrotic Syndrome with Spleen and Kidney Yang Deficiency Type Using Modified Shipiyin Combined with Western Medicine Therapy

作　　者：赵秋扬 田帅 张磊 吴新萍 刘红莉 王红军 ZHAO Qiuyang;TIAN Shuai;ZHANG Lei;WU Xinping;LIU Hongli;WANG Hongjun(Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian Henan 463000,China)

机构地区：[1]驻马店市中医院,河南驻马店463000

出　　处：《药品评价》2024年第12期1500-1503,共4页Drug Evaluation

摘　　要：目的分析实脾饮加减联合常规西医疗法治疗脾肾阳虚型肾病综合征(NS)患者的效果。方法选取2022年3月至2024年3月驻马店市中医院收治的98例脾肾阳虚型NS患者,按随机数字表法分为两组,各49例。对照组行常规西医疗法,观察组加以实脾饮加减治疗。比较两组临床疗效、中医证候评分、肾功能指标及不良反应。结果观察组治疗总有效率(95.92%)高于对照组(83.67%),且治疗后的各中医证候评分均低于对照组,差异有统计学意义(P<0.05);观察组尿素氮、血肌酐(Scr)、24 h尿蛋白定量水平低于对照组,血清白蛋白水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论实脾饮加减联合常规西医疗法能减轻脾肾阳虚型NS患者症状,加快肾功能恢复,且不会增加不良反应。Objective To analyze the effect of modified shipiyin combined with conventional western medicine therapy in patients nephrotic syndrome(NS)with spleen and kidney yang deficiency.Methods 98 patients with spleen and kidney yang deficiency NS admitted in Zhumadian Hospital of Traditional Chinese Medicine from March 2022 to March 2024 were divided into two groups,with 49 cases in each group.The control group received conventional western medicine therapy,and the observation group received modified shipiyin on the basis of the control group.Compare the clinical efficacy,traditional Chinese medicine syndrome scores,renal function indicators[blood urea nitrogen(BNU),serum creatinine(Scr),albumin,24 h urinary protein quantification]and the occurrence of adverse reactions.Results The overall response rate in the observation group was 95.92%,which was higher than 83.67%in the control group,and the scores of each TCM syndrome after treatment were all lower than those in the control group,with statistically significant differences(P<0.05);BNU,Scr,24 h urinary protein quantification levels were lower than those in the control group,serum albumin level was higher than that in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified shipiyin combined with conventional western medicine therapy can reduce the symptoms of spleen and kidney yang deficiency in NS patients and accelerate the recovery of renal function without increasing the adverse effects.

关 键 词：肾病综合征 脾肾阳虚型 实脾饮 不良反应 

分 类 号：R692[医药卫生—泌尿科学]