醒脑静注射液联合奥拉西坦注射液对脑外伤患者神经功能的影响及预后分析  

Effect and prognostic analysis of refreshing static injection combined with oxiracetam injection on neurological function in patients with brain trauma

作　　者：张继禹 周康 ZHANG Jiyu;ZHOU Kang(Department of Neurosurgery,Pukou Hospital of Traditional Chinese Medicine,Nanjing,Jiangsu 211800)

机构地区：[1]江苏省南京市浦口区中医院神经外科,江苏南京211800

出　　处：《河北中医》2025年第4期581-584,共4页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察醒脑静注射液联合奥拉西坦注射液对脑外伤神经功能的影响及预后情况。方法选取2022年4月到2023年4月收治的40例脑外伤患者为研究对象,按照随机数字表法者分为研究组20例与对照组20例,对照组予以奥拉西坦注射液治疗,研究组在对照组基础上联合醒脑静注射液治疗。2组均治疗28 d,比较2组治疗前及治疗14、28 d后神经功能美国国立卫生研究院卒中量表(NIHSS)评分和伦多临床评分系统(CSS)评分变化情况,比较2组治疗前及治疗28 d后神经元损伤与修复指标神经元特异性烯醇化酶(NSE)、S100B、胶质纤维酸性蛋白(GFAP)、髓鞘碱性蛋白(MBP)、热休克蛋白-27(HSP-27)、HSP-70、HSP-90水平变化情况,比较2组预后情况与不良反应的差异。结果与本组治疗前比较,2组治疗14、28 d后NIHSS评分、CSS评分均降低(P<0.05);与本组治疗14 d后比较,2组治疗28 d后NIHSS评分、CSS评分进一步降低(P<0.05);与对照组治疗后同期比较,研究组治疗14、28 d后NIHSS评分、CSS评分均低于对照组治疗后同期水平(P<0.05)。与本组治疗前比较,2组治疗28 d后NSE、S100B、GFAP、MBP、HSP-27、HSP-70、HSP-90水平均降低(P<0.05),且研究组治疗后NSE、S100B、GFAP、MBP、HSP-27、HSP-70、HSP-90水平均低于对照组(P<0.05)。2组预后情况比较差异存在统计学意义(Z=4.333,P<0.05),且研究组预后优良率高于对照组(P<0.05),但2组不良反应发生率比较差异无统计学意义(χ^(2)=1.111,P>0.05)。结论醒脑静注射液联合奥拉西坦注射液治疗脑外伤患者可有效缓解神经损伤,促进神经功能修复,改善预后。Objective To explore the effect and prognostic analysis of refreshing static injection combined with oxiracetam injection on neurological function in patients with brain trauma.Methods Forty patients with brain trauma admitted from April 2022 to April 2023 were randomly assigned into study group(n=20)and control group(n=20).All patients were managed by oxiracetam injection,and those in study group were additionally treated with refreshing static injection.Treated for 28 days,National Institutes of Health Stroke Scale(NIHSS),Toronto Clinical Scoring System(CSS)scores on day 0,and on days 14 and 28,neuron-specific enolase[NSE],S100 calcium-binding protein beta subunit[S100B]protein,glial fibrilary acidic protein[GFAP],myelin basic protein[MBP],Heat shock protein-27[HSP-27],HSP-70,HSP-90 on day 0,and on day 28,prognosis,and adverse reactions between groups were included as comparators.Results NIHSS and CSS scores on days 14 and 28 in the both groups were significantly decreased than those before treatment(P<0.05),which on day 28 in the both groups were significantly decreased than those on day 14(P<0.05).NIHSS and CSS scores on days 14 and 28 were significantly lower in the study group than in the control group(P<0.05).The levels of NSE,S100B,GFAP,MBP,HSP-27,HSP-70,HSP-90 on day 28 in the both groups were significantly decreased than those before treatment(P<0.05),the decrease in the study group was more common than the control group(P<0.05).There was a statistically significant difference in prognosis between the two groups(Z=4.333,P<0.05),and the study group had a better prognosis than the control group(P<0.05).None of the incidence of adverse reactions differed significantly between groups(χ^(2)=1.111,P>0.05).Conclusion Refreshing static injection combined with oxiracetam injection can effectively relieve nerve injury,promote nerve function repair and improve prognosis in patients with brain trauma.

关 键 词：脑外伤 中西医结合疗法 中成药 

分 类 号：R651.1[医药卫生—外科学]