多囊卵巢综合征不孕症患者血清sRAGE、CTRP3水平与IVF-ET助孕妊娠结局的相关性  

Levels of serum soluble receptor for advanced glycation end product and complement C1q/tumor necrosis factor-related protein 3 in infertile patients with polycystic ovary syndrome and their correlation with in vitro fertilization-embryo transfer assisted pregnancy outcomes

作　　者：赵静[1] 狄树平 张红霞[1] ZHAO Jing;DI Shuping;ZHANG Hongxia(Department of Obstetrics,Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Cangzhou 061001,Hebei,China;Department of Clinical Reproduction,Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Cangzhou 061001,Hebei,China)

机构地区：[1]河北省沧州中西医结合医院妇产科,河北沧州061001 [2]河北省沧州中西医结合医院临床生殖科,河北沧州061001

出　　处：《中国性科学》2025年第4期42-46,共5页Chinese Journal of Human Sexuality

基　　金：河北省中医药管理局项目(2021316)。

摘　　要：目的探究多囊卵巢综合征(PCOS)不孕症患者血清可溶性晚期糖基化终末产物受体(sRAGE)、补体C1q/肿瘤坏死因子相关蛋白3(CTRP3)水平与体外受精-胚胎移植(IVF-ET)助孕妊娠结局的相关性。方法选取2021年1月至2023年1月河北省沧州中西医结合医院收治的98例行IVF-ET助孕的PCOS不孕症患者设为研究组,并根据助孕后妊娠结局分为妊娠组和未妊娠组。另选取同期98例行IVF-ET助孕的非PCOS不孕症患者设为对照组。检测两组sRAGE、CTRP3水平,分析PCOS不孕症患者IVF-ET助孕妊娠结局的影响因素,分析血清sRAGE、CTRP3水平对PCOS不孕症患者IVF-ET助孕妊娠结局的预测价值。结果研究组血清sRAGE水平高于对照组,CTRP3水平低于对照组(P<0.05)。研究组卵子成熟率、受精率、优胚率和临床妊娠率小于对照组(P<0.05)。未妊娠组血清sRAGE水平高于妊娠组,CTRP3水平低于妊娠组(P<0.05)。体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)、睾酮、sRAGE是影响PCOS不孕症患者妊娠结局的危险因素(P<0.05)。血清sRAGE联合CTRP3预测PCOS不孕症患者IVF-ET助孕妊娠结局的曲线下面积(AUC)优于血清sRAGE、CTRP3单独预测(P<0.05)。结论PCOS不孕症患者血清sRAGE水平升高,CTRP3水平降低,二者均与IVF-ET助孕妊娠结局相关,二者联合检测对PCOS不孕症患者IVF-ET助孕妊娠结局的预测价值更高。Objective To investigate serum soluble receptor for advanced glycation end product(sRAGE)and complement C1q/tumor necrosis factor-related protein 3(CTRP3)levels in infertile patients with polycystic ovary syndrome(PCOS)and their correlation with in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcomes.Methods A total of 98 infertile patients with PCOS who admitted to Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine and underwent IVF-ET assisted pregnancy were selected as the study group and divided into pregnancy group and non-pregnancy group according to the pregnancy outcome after assisted pregnancy.In addition,98 non-PCOS infertile patients who underwent IVF-ET assisted pregnancy were selected as the control group.The levels of sRAGE and CTRP3 in the two groups were detected,the influencing factors of IVF-ET assisted pregnancy outcomes in PCOS infertile patients were analyzed,and the predictive value of serum sRAGE and CTRP3 levels on IVF-ET assisted pregnancy outcomes in PCOS infertile patients was analyzed.Results The serum sRAGE level in the study group were higher than those in the control group,the serum CTRP3 level in the study group were lower than those in the control group(P<0.05).The egg maturity rate,fertilization rate,high-quality embryo rate and clinical pregnancy rate in the study group were lower than those in the control group(P<0.05).The serum sRAGE level in the non-pregnant group were higher than those in the pregnant group,the serum CTRP3 level in the non-pregnant group were lower than those in the pregnant group(P<0.05).Body mass index(BMI),insulin resistance index(HOMA-IR),testosterone and sRAGE were risk factors for pregnancy outcomes in infertile patients with PCOS(P<0.05).The area under the curve(AUC)of serum sRAGE combined with CTRP3 in predicting pregnancy outcomes in IVF-ET assisted pregnancy in infertile patients with PCOS was better than that of serum sRAGE and CTRP3 alone prediction(P<0.05).Conclusions The increase of serum s

关 键 词：多囊卵巢综合征 不孕症 可溶性晚期糖基化终末产物受体 补体C1q/肿瘤坏死因子相关蛋白3 体外受精-胚胎移植 妊娠结局 

分 类 号：R711[医药卫生—妇产科学]