太赫兹连续域束缚态超表面用于抗生素质量浓度检测  

Terahertz Metasurface with Bound States in Continuum for Antibiotic Mass Concentration Detection

作　　者：杨帆 佘硕铖 李继涛 丁欣[1] 姚建铨[1] Yang Fan;She Shuocheng;Li Jitao;Ding Xin;Yao Jianquan(Institute of Laser and Opto-Electronics,School of Precision Instruments and Opto-Electronics Engineering,Tianjin University,Tianjin,300072,China)

机构地区：[1]天津大学精密仪器与光电子工程学院激光与光电子研究所,天津300072

出　　处：《中国激光》2025年第1期244-253,共10页Chinese Journal of Lasers

基　　金：国家自然科学基金(U22A2008,62175181);国家重点研发项目(2021YFB2800703,2022YFA1203502);崂山实验室科技创新项目(LSKJ202200801)。

摘　　要：连续域中的束缚态(BIC)能够促进光与物质之间的强相互作用,将其引入到超表面,可以实现超高Q共振。通过结合太赫兹技术无损检测的优点,基于BIC的太赫兹超表面在生物和化学传感中得到了广泛应用。设计了一种支持太赫兹BIC的金属超表面,并将其用于抗生素质量浓度检测。仿真和实验结果表明,通过破坏结构对称性,可将BIC转变为可观测的准BIC。所设计的基于BIC的传感器的折射率灵敏度理论值达到210 GHz·RIU^(-1)(RIU为折射率单位),传感器具有优异的传感性能,对青霉素G钾盐的检测极限达到0.625 mg·mL^(-1),在低质量浓度抗生素检测中展现出了巨大的应用潜力。研究结果为抗生素的高灵敏度、快速和无损检测提供了新的思路和方法,在生化传感领域中具有广阔的应用前景。Objective Antibiotics produced by microorganisms(such as bacteria and fungi)or through semi-synthetic and synthetic methods are a class of drugs primarily used to treat various infections caused by bacteria or fungi.The misuse and overuse of antibiotics have resulted in severe problems caused by antibiotic resistance.To ensure the effective use and management of antibiotics,one must detect their concentrations precisely.Conventional methods for detecting antibiotics require professional operational technology and complex instruments;moreover,the associated procedure is cumbersome and lengthy.Therefore,an efficient,rapid,and highly sensitive method for detecting antibiotic concentrations must be devised.Bound states in the continuum(BICs)can promote strong interactions between light and matter,which are introduced into the metasurface to achieve ultrahigh Q resonance.Combined with the advantages of terahertz technology in nondestructive testing,terahertz metasurfaces based on BICs have been widely used in biological and chemical sensing.A metasurface with BICs and a high Q-factor can significantly improve the sensitivity of a biosensor to slight environmental changes,thus providing an effective scheme for the rapid,convenient,and highly sensitive detection of antibiotics.Methods A metallic structure was designed on a 500-µm-thick quartz substrate.The transition from BICs to quasi-BICs was achieved by introducing asymmetric parameters.The transmitted spectra for different parameters l_(1)were simulated using CST Studio with a time-domain solver.In the simulation,the x-and y-directions were set as periodic boundary conditions,and the z-direction was set as an open-boundary condition.BICs can be excited under both x-and y-polarization incidences.The far-field scattering power of the structure was analyzed via Cartesian multipole decomposition based on electromagnetic multipole theory.A series of samples with different parameters was prepared and verified using a terahertz time-domain spectroscopy(THz-TDS)system.Addi

关 键 词：光学 太赫兹 超表面 连续域束缚态 传感 

分 类 号：O436[机械工程—光学工程]