子宫内膜癌组织中HDAC1、FRS2表达水平及临床预后意义  

Expression Levels of HDAC1 and FRS2 in Endometrial Carcinoma and Their Prognostic Significance

作　　者：罗莉[1] 杨旭 韩建雄 吴虹苇 罗大先 LUO Li;YANG Xu;HAN Jianxiong;WU Hongwei;LUO Daxian(Department of Obstetrics and Gynecology,The Fifth People's Hospital of Chengdu,Chengdu,Sichuan 610031,China;Department of Gastroenterology,The Fifth People's Hospital of Chengdu,Chengdu,Sichuan 610031,China;Department of Oncology,Affiliated Hospital of Guizhou Medical University,Guiyang,Guihzou 550004,China)

机构地区：[1]成都市第五人民医院妇产科,四川成都610031 [2]成都市第五人民医院消化内科,四川成都610031 [3]贵州医科大学附属医院肿瘤科,贵州贵阳550004

出　　处：《转化医学杂志》2025年第3期83-88,共6页Translational Medicine Journal

基　　金：四川省科技计划项目(2022JDRC0141)。

摘　　要：目的探讨子宫内膜癌组织中组蛋白去乙酰化酶1(HDAC1)、成纤维细胞生长因子受体底物2(FRS2)表达水平及临床预后意义。方法选取2018年1月至2021年12月成都市第五人民医院妇产科收治的201例子宫内膜癌患者,将癌组织标本设立为子宫内膜癌组,癌旁组织标本设立为癌旁组,每组201例。采用免疫组化法检测组织中HDAC1、FRS2表达情况。比较不同临床病理特征患者的HDAC1、FRS2表达,采用多因素Cox回归分析探讨患者预后影响因素。结果子宫内膜癌组HDAC1、FRS2的阳性表达率(73.13%、69.65%)均高于癌旁组(33.83%、38.32%),差异有统计学意义(P<0.05)。组织学分级为G3、FIGO分期为Ⅲ期、淋巴结转移、肌层浸润>1/2的子宫内膜癌患者HDAC1阳性表达率、FRS2阳性表达率均高于子宫内膜癌组织学分级为G1+G2、FIGO分期为Ⅰ期+Ⅱ期、无淋巴结转移、肌层浸润<1/2的患者(P<0.05)。201例子宫内膜癌患者随访3年总生存率为80.60%(162/201)。HDAC1、FRS2阴性患者的3年总生存率高于HDAC1、FRS2阳性患者(P<0.05)。多因素Cox回归分析显示:组织学分级G3(HR=2.401,95%CI:1.205~4.787)、FIGO分期Ⅲ期(HR=2.519,95%CI:1.447~4.387)、淋巴结转移(HR=2.858,95%CI:1.436~5.686)、肌层浸润>1/2(HR=2.570,95%CI:1.328~4.975)、HDAC1阳性(HR=3.086,95%CI:1.731~5.502),FRS2阳性(HR=3.892,95%CI:1.999~7.579)是影响子宫内膜癌患者预后的因素(P<0.05)。结论子宫内膜癌组织中HDAC1和FRS2的高表达与患者的不良预后显著相关,且组织学分级G3、FIGO分期Ⅲ期、淋巴结转移和肌层浸润>1/2也是影响其预后的不利因素。Objective To explore the expression levels of histone deacetylase 1(HDAC1)and fibroblast growth factor receptor substrate 2(FRS2)in endometrial carcinoma and their prognostic significance.Methods A total of 201 endometrial cancer patients admitted to our hospital from January 2018 to December 2021 were included.Cancer tissue specimens were designated as the endometrial carcinoma group(n=201)and adjacent normal tissue specimens were designated as the paracancerous group(n=201).The expressions of HDAC1 and FRS2 in tissues were detected by immunohistochemistry.The expression levels of HDAC1 and FRS2 in patients with different clinicopathological characteristics were compared,and the prognostic factors were analyzed using multivariate Cox regression.Results The positive rates of HDAC1 and FRS2 in endometrial carcinoma group(73.13%、69.65%)were higher than those in paracancerous group(33.83%、38.32%)(P<0.05).Patients with G3 histological grade,FIGO stageⅢ,lymph node metastasis,or myometrial invasion>1/2 exhibited higher HDAC1 and FRS2 positivity compared to those with G1+G2 histological grade,FIGO stageⅠ+Ⅱ,no lymph node metastasis,or myometrial invasion<1/2(P<0.05).Among the 201 patients,162 cases survived,yielding an overall survival rate of 80.60%(162/201).The 3-year overall survival rate was higher in HDAC1-negative and FRS2-negative patients than in HDAC1-positive and FRS2-positive patients(P<0.05).Multivariate Cox regression analysis showed that histological grade G3(HR=2.401,95%CI:1.205-4.787),FIGO stageⅢ(HR=2.519,95%CI:1.447-4.387),lymph node metastasis(HR=2.858,95%CI:1.436-5.686),muscle infiltration>1/2(HR=2.570,95%CI:1.328-4.975),HDAC1 positive(HR=3.086,95%CI:1.731-5.502),FRS2 positive(HR=3.892,95%CI:1.999-7.579)were the prognostic factors of cases with endometrial carcinoma(P<0.05).Conclusion High expression of HDAC1 and FRS2 in endometrial carcinoma is associated with poor prognosis.Additionally,histological grade G3,FIGO stageⅢ,lymph node metastasis,and muscular infiltration>1/2 are adverse pro

关 键 词：子宫内膜癌 组蛋白去乙酰化酶1 成纤维细胞生长因子受体底物2 预后 

分 类 号：R711[医药卫生—妇产科学]