儿童肝移植的现状与展望  

Current status and prospects of pediatric liver transplantation

作　　者：刘源[1] 夏强[1] Liu Yuan;Xia Qiang(Department of Liver Surgery,Renji Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院肝脏外科,上海200127

出　　处：《中华外科杂志》2025年第4期300-305,共6页Chinese Journal of Surgery

摘　　要：随着手术技术和围手术期管理水平的发展和提高,儿童肝移植术后总体生存率不断升高,肝移植成为治疗儿童终末期肝病最有效的手段。儿童肝移植受者的长期生存受到原发疾病、手术时机、手术方式和术后管理等一系列因素的影响,如何建立移植术后个体化管理方案,降低术后并发症发生率,提高移植患儿长期生活质量成为目前研究的重点。本文从儿童肝移植的发展历史、手术适应证、手术创新与发展、术后免疫抑制剂方案与长期随访管理等5个方面,阐述儿童肝移植的现状与未来展望,以期进一步推动我国儿童肝移植相关领域的发展。With the development and improvement of surgical techniques and perioperative management,the overall survival rate after pediatric liver transplantation has continued to improve.Liver transplantation has become the most effective treatment for end-stage liver disease in children.The long-term survival of pediatric liver transplant recipients is affected by a series of factors such as primary disease,surgical timing,surgical method,and postoperative management.How to establish an individualized management plan after transplantation,reduce the incidence of postoperative complications,and improve the long-term quality of life after transplantation has become the focus of current research.This paper explores the current status and future prospects of pediatric liver transplantation from five aspects:the development history of pediatric liver transplantation,surgical indications,surgical innovation and development,postoperative immunosuppressant regimens,and long-term follow-up management,in order to further promote the development of pediatric liver transplantation in the future.

关 键 词：肝移植 儿童 适应证 活体肝移植 免疫耐受 长期管理 

分 类 号：R726.5[医药卫生—儿科]