生物质及生物质相关止血材料的研究进展  

Research progress on biomass and biomass-related hemostatic materials

作　　者：敖青 张戈 丁功涛 王子凡 Teow Yeit Haan Sajab Mohd Shaiful 马忠仁[1] 赵蕾 AO Qing;ZHANG Ge;DING Gongtao;WANG Zifan;TEOW Yeit Haan;SAJAB Mohd Shaiful;MA Zhongren;ZHAO Lei(Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Faculty of Engineering and Built Environment,The National University of Malaysia,Bangi 43600,Selangor Darul Ehsan,Malaysia)

机构地区：[1]西北民族大学生物医学研究中心,兰州730030 [2]马来西亚国立大学工程与建筑环境学院,雪兰莪州,万宜镇43600

出　　处：《复合材料学报》2025年第3期1246-1260,共15页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(22104045);甘肃省自然科学基金(23JRRA1733;23JRRA718)。

摘　　要：伤口的快速止血和愈合对于解决意外事故造成的出血具有重要意义,相关止血材料的开发和应用一直备受关注。以角蛋白、丝素蛋白、胶原蛋白为代表的蛋白类和以纤维素、壳聚糖、海藻酸为代表的多糖类等生物质材料,因其无毒性、低抗原性、良好的生物相容性、生物可降解性等优点在止血领域展现了前所未有的应用价值。基于此,本文对生物质止血材料的设计、制备及止血应用的最新研究进展进行了全面综述,并对其发展前景做了展望,以期为新型高效止血材料的开发和实际应用提供思路。The rapid hemostasis and healing of wounds after trauma hold great significance to solve the bleeding caused by accidents.Therefore,the development and application of related hemostatic materials have attracted much attention.Biomass-derived materials such as proteins including keratin,silk fibroin,collagen and polysaccharides including cellulose,chitosan,and alginic acid are favored by researchers because of their non-toxicity,low antigenicity,good biocompatibility,and biodegradability,and have shown unprecedented application value in the field of hemostasis.In this paper,the latest research results on the design,the preparation and the application of biomass hemostatic materials are comprehensively reviewed,and their development prospects are prospected,which will provide ideas for the development and practical application of new high-efficiency hemostatic materials.

关 键 词：生物质材料 蛋白质 多糖 止血性能 伤口止血 

分 类 号：O636.9[理学—高分子化学] TB332[理学—化学]