高压氧改善病毒性肺炎后遗症状的临床研究  

Clinical study of hyperbaric oxygen improving sequelae of viral pneumonia

作　　者：蔡仁萍 姜俊宇 张翠翠 李向东 Cai Renping;Jiang Junyu;Zhang Cuicui;Li Xiangdong(Department of Respiratory Medicine,the Eighth People’s Hospital of Jinan,Jinan 271104,China;Department of Reparative and Reconstructive Surgery,Shandong Public Health Clinical Center,Jinan 250000,China)

机构地区：[1]济南市第八人民医院呼吸科,济南271104 [2]山东省公共卫生临床中心修复重建外科,济南250000

出　　处：《中华航海医学与高气压医学杂志》2025年第3期296-300,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：山东省医药卫生科技发展计划(2018WS444);济南市卫生健康委员会科技计划(2020-4-150,2021-2-63)。

摘　　要：目的探讨高压氧(HBO)对病毒性肺炎(VP)后咳嗽等后遗症状的改善作用。方法选择2022年12月至2023年12月济南市第八人民医院和山东省公共卫生临床中心收治的病毒性肺炎患者100例,按照随机数字表法,分为对照组(50例)和观察组(50例)。在常规治疗基础上,对照组给予普通氧疗,观察组给予HBO治疗。2组患者均在入组前及治疗半个月后测量中文版莱切斯特咳嗽问卷(LCQ)、血气分析、呼出气一氧化氮(FENO)、白细胞介素-6(IL-6)和T淋巴细胞亚群的变化。结果LCQ结果比较,观察组患者生理维度、心理维度及总评分分别为(5.46±1.41)分、(4.76±0.85)分和(13.23±2.32)分,均高于本组治疗前及对照组治疗后,差异均有统计学意义(均P<0.05)。观察组FENO、IL-6分别为(19.78±5.26)×10-6、(3.07±1.08)pg/ml,均低于本组治疗前及对照组治疗后,差异均有统计学意义(均P<0.05)。氧分压、血氧饱和度分别为(61.02±5.04)mmHg和(92.33±4.78)mmHg,均高于本组治疗前及对照组治疗后,差异均有统计学意义(均P<0.05)。T淋巴细胞亚群比较,观察组患者治疗后CD3%、CD4%和CD4/CD8分别为(54.13±8.81)%、(31.87±9.65)%和1.17±0.15,均较本组治疗前及对照组治疗后升高,差异均有统计学意义(均P<0.05);CD8%治疗前后差异无统计学意义(P>0.05)。结论HBO能降低VP患者气道高反应性,减轻咳嗽、咳痰症状,纠正缺氧,提高免疫功能,改善生活质量。Objective To investigate the effect of hyperbaric oxygen(HBO)on the improvement of sequelae such as coughing after viral pneumonia(VP).Methods The patients with viral pneumonia admitted to Eighth People’s Hospital of Jinan and Shandong Public Health Clinical Center from December 2022 to December 2023 were selected.According to the random number table method,they were divided into control group(50 cases)and observation group(50 cases).On the basis of conventional treatment,the control group was given ordinary oxygen therapy,while the observation group was given HBO therapy.In both groups,a survey was carried out using the Chinese version of Leicester cough questionnaire(LCQ),the values of blood gas analysis and fractional exhaled nitric oxide(FENO),and the levels of interleukin-6(IL-6)and T lymphocyte subsets were measured before enrollment and after half a month treatment.Results After treatment,the LCQ scores for the observation group were as follows:physiological dimension(5.46±1.41),psychological dimension(4.76±0.85),and total score(13.23±2.32).These scores were significantly higher than those before treatment in the same group and those after treatment in the control group,with all differences being statistically significant(all P<0.05).After treatment,the FENO values and IL-6 levels in the observation group were(19.78±5.26)×10-6 and(3.07±1.08)pg/ml,respectively,which were significantly lower than those before treatment in the same group and those after treatment in the control group,with the differences being statistically significant(all P<0.05).The partial pressure of oxygen and blood oxygen saturation were(61.02±5.04)mmHg and(92.33±4.78)mmHg,respectively,which were significantly higher than those before treatment in the same group and those after treatment in the control group,with all differences being statistically significant(all P<0.05).In terms of T lymphocyte subsets,after treatment,the observation group showed increased levels of CD3%,CD4%,and CD4/CD8 ratio,which were(54.13±8.81)%,(31.87

关 键 词：高压氧 病毒性肺炎 呼出气一氧化氮 中文版莱切斯特咳嗽量表 

分 类 号：R563.1[医药卫生—呼吸系统]