济南市历城区育龄女性红细胞叶酸浓度调查分析  

Investigation Analysis of Red Blood Cell Folic Acid Concentration in Women of Childbearing Age in Licheng District of Jinan

作　　者：赵俭 王秀蕾 孙莉 陈燕 何冰 Zhao Jian;Wang Xiulei;Sun Li;Chen Yan;He Bing(Maternal and Child Health and Family Planning Service Center in Licheng District,Jinan,Shandong,250100,China)

机构地区：[1]济南市历城区妇幼保健计划生育服务中心,山东济南250100

出　　处：《中国初级卫生保健》2025年第4期33-35,共3页Chinese Primary Health Care

基　　金：2023年济南市妇幼健康研究课题(2023-FY-01)。

摘　　要：目的:了解济南市历城区育龄女性体内叶酸水平,指导备孕妇女合理补充叶酸,以降低新生儿出生缺陷发生率。方法:选取2023年7月—2024年6月在历城区妇幼保健计划生育服务中心进行红细胞叶酸浓度项目检测的育龄女性393人,分析其红细胞叶酸浓度差异,比较参加(n=117)及未参加(n=165)红细胞叶酸浓度检测的育龄女性叶酸服用依从性差异。结果:393名历城区女性平均红细胞叶酸浓度为254.74 ng/mL,其中达不到备孕要求(<400.0 ng/mL)者341人,占86.77%。<30岁女性平均红细胞叶酸浓度为235.10 ng/mL,明显低于≥30岁女性的平均红细胞叶酸浓度(300.16 ng/mL)。服用叶酸前,叶酸服用剂量为0.4 mg组和0.8 mg组女性平均红细胞叶酸浓度分别为206.83 ng/mL和267.63 ng/mL,差异无统计学意义(P>0.05)。服用叶酸后,叶酸服用剂量为0.8 mg组女性平均红细胞叶酸浓度为677.10 ng/mL,明显高于0.4 mg组(377.37 ng/mL),差异有统计学意义(t=-3.491,P<0.05)。孕前优生健康检查中参加红细胞叶酸浓度检测的女性叶酸服用依从率为63.24%(74/117),高于未参加检测的女性[37.58%(62/165)]。结论:历城区育龄女性叶酸总体水平较低,且年龄越小者红细胞叶酸浓度越低。孕前服用0.4 mg叶酸3个月并不能达到备孕要求,各地应探索个性化叶酸增补方案,提升女性叶酸服用依从性,减少出生缺陷的发生。OBJECTIVE To understand the folic acid status of reproductive-age women in Licheng District of Jinan,and to advise women planning to conceive on optimal folic acid supplementation to reduce the risk of fetal birth defects.METHODS Select 393 women of childbearing age who underwent red blood cell folate concentration testing at Maternal and Child Health and Family Planning Service Center in Licheng District of Jinan from July 2023 to June 2024,and analyze the differences in their red blood cell folate concentration.A survey was conducted to compare the differences in folate adherence between women of childbearing age who participated(n=117)and those who did not participate(n=165)in red blood cell folate concentration testing.RESULTS The average erythrocyte folate concentration of 393 women of childbearing age in Licheng District was 254.74 ng/ml,and 341(86.77%)were below the requirement for pregnancy preparation(<400.0 ng/mL).The red blood cell folate concentration was significantly lower in the<30 years group(235.1 ng/mL)than in the>30 years group(300.16 ng/mL).There was no significant difference in red blood cel folate concentration between the two groups before taking different doses of folic acid(P>0.05).After taking folic acid,the red blood cell folate concentration in the 0.8 mg dose group(677.10 ng/mL)was higher than that in the 0.4 mg dose group(377.37 ng/mL)(t=-3.491,P<0.05).The compliance of red blood cell folic acid intake was higher in those who took part in red blood cell folic acid test[63.24%(74/117)]than those who did not take part in the test[37.58%(62/165)].CONCLUSION The overall level of folate in women of childbearing age in Licheng district of Jinan was low,and the younger the women were,the lower the red blood cell folate concentration was.Taking 0.4 mg folic acid for 3 months before pregnancy does not meet the requirements of pregnancy preparation.Local governments should explore individualized folic acid supplementation programs to improve the compliance of folic acid supplementation and red

关 键 词：叶酸 胎儿神经管缺陷 红细胞叶酸浓度 叶酸服用依从性 

分 类 号：R173[医药卫生—妇幼卫生保健]