注射用艾普拉唑治疗消化性溃疡出血低危患者的药物经济学评价  

Economic Evaluation of Ilaprazole Injection in Patients with Peptic Ulcer Bleeding and Low-Risk Stigmata

作　　者：利亭婷 祝赫 赵利娜 孙旭[1,2] 苏芬丽[1,2] 熊芬 唐洪梅[1,2] LI Tingting;ZHU He;ZHAO Lina;SUN Xu;SU Fenli;XIONG Fen;TANG Hongmei(Department of Pharmacy,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Guangdong Clinical Research Academy of Chinese Medicine,Guangzhou 510405,China;Department of Digestion,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院药学部,广州510405 [2]广东省中医临床研究院,广州510405 [3]广州中医药大学第一附属医院脾胃病科,广州510405

出　　处：《医药导报》2025年第5期758-763,共6页Herald of Medicine

基　　金：国家自然科学基金青年项目(82204891);广东省基础与应用基础研究项目(2021A1515110727);广州市科技计划项目(202201020493);广东省中医药管理局科研项目(20231126)。

摘　　要：目的评价艾普拉唑治疗消化性溃疡出血低危患者的经济性,为质子泵抑制剂的选用提供参考。方法从全社会角度出发,构建住院期间艾普拉唑对比奥美拉唑治疗消化性溃疡出血低危患者的决策树模型。模型结点转移率来自Ⅲ期临床试验研究结果数据。采用最小成本分析法分析经济性,成本数据来自国家医疗保险谈判价格和省级中标价格、医院数据库、文献等。采用单因素敏感性分析、概率敏感性分析和情景分析检验结果稳定性。结果在基本设定下,艾普拉唑组和奥美拉唑钠组的治疗成本分别为4038.99、3837.61元,艾普拉唑组的治疗成本较奥美拉唑钠组高201.38元。敏感性分析显示结果稳定,但情景分析显示以注射用奥美拉唑的原研药品作为对照时,结果将反转。结论消化性溃疡出血低危患者选用注射用艾普拉唑经济性不及注射用奥美拉唑。Objective To perform an economic evaluation of ilaprazole in the treatment of patients with peptic ulcer bleeding and low-risk stigmata,and to provide a reference for drug selection.Methods From a societal perspective,we used decision analysis to evaluate the cost and effectiveness of ilaprazole and omeprazole in treating peptic ulcer bleeding patients during hospital stays.The probabilities of model nodes were taken from phaseⅢclinical trial research results,while cost data came from national medical insurance prices,published literature,and hospital databases.Sensitivity analysis and scenario analysis were performed to test the stability of the results.Results A cost minimization analysis was performed.Under the basic setting,the cost of the ilaprazole group was 4038.99 yuan,and that of the omeprazole group was 3837.61 yuan,which means that the cost of the ilaprazole group was 201.38 yuan higher.Sensitivity analysis showed that the results were stable.Scenario analysis showed that ilaprazole was more cost-effective than the innovator drug of omeprazole.Conclusion Ilaprazole was less economical than omeprazole in the treatment of peptic ulcer bleeding patients with low-risk stigmata.

关 键 词：艾普拉唑 奥美拉唑 消化性溃疡出血 决策树模型 药物经济学 最小成本分析 

分 类 号：R975.2[医药卫生—药品] R969.3[医药卫生—药学]