卡度尼利单抗致1型糖尿病不良反应的药学监护  

Pharmaceutical Monitoring of Adverse Reactions of Type 1 Diabetes Induced by Cardonilimab

作　　者：吴丹丹[1] 解敏 孙绍伟[1] 李瑞霞 孙超[2] 刘明华[1] WU Dandan;XIE Min;SUN Shaowei;LI Ruixia;SUN Chao;LIU Minghua(Department of Pharmacy,Binzhou Medical University Hospital,Binzhou 256603,China;Department of Endocrinology,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院药学部,滨州256603 [2]滨州医学院附属医院内分泌科,滨州256603

出　　处：《医药导报》2025年第5期791-795,共5页Herald of Medicine

摘　　要：目的探讨卡度尼利单抗治疗肺癌过程中发生1型糖尿病不良反应的识别,及患者血糖管理的药学监护,为相关疾病的预防、治疗和药学服务提供参考。方法临床药师协助医生对1例肺癌患者使用卡度尼利单抗免疫治疗出现1型糖尿病后进行药品不良反应判断、可疑药物识别,同时参考循证证据为临床治疗提供建议,并对患者的血糖管理进行用药教育、药学监护和长期随访。结果患者经胰岛素强化治疗及饮食控制后,高糖症状缓解,血糖逐渐趋于稳定,并继续挑战使用卡度尼利单抗免疫治疗,病情稳定。结论临床药师协助医师及时识别药品不良反应,并参与患者用药的全程管理,在治疗团队中发挥积极治疗作用,体现了药学服务价值。Objective To explore the identification of adverse reactions of type 1 diabetes during lung cancer treatment with cardonilimab and the pharmaceutical monitoring of patient's blood glucose management,and to accumulate experience for the prevention,treatment,and pharmaceutical services of related diseases.Methods The clinical pharmacist assisted doctors in judging adverse drug reactions and identifying suspicious drugs in a patient with lung cancer who developed type 1 diabetes.At the same time,the clinical pharmacist provided suggestions for clinical treatment by referring to clinical evidence,and providing medication education,pharmaceutical care,and long-term follow-up for the patient's blood glucose management.Results After intensive insulin therapy and dietary control,the patient's high glucose symptoms were relieved,and the blood glucose gradually stabilized.The patient continued to be challenged using cardonilimab immunotherapy,and the condition was stable.Conclusions Clinical pharmacists assist physicians in identifying adverse drug reactions on time and participate in the full process management of patient medication.They play an active therapeutic role in the medical team and reflect the value of pharmaceutical services.

关 键 词：卡度尼利单抗 糖尿病 临床药师 药学服务 

分 类 号：R979.1[医药卫生—药品] R969.3[医药卫生—药学]