纳武利尤单抗致相关性肾上腺皮质功能不全1例  

A Case of Nivolumab-related Adrenal Cortical Insufficiency

作　　者：王蓓蓓 李晓琳 都彩莹 耿继红 全香花[4] WANG Beibei;LI Xiaolin;DU Caiying;GENG Jihong;QUAN Xianghua(Department of Pharmacy,Affiliated Hospital of Yangzhou University,Yangzhou 225001,China;Department of Pharmacy,Dong'e County People's Hospital of Shandong Province,Dong'e 252299,China;College of Pharmacy,Yanbian University,Yanji 133002,China;Department of Pharmacy,Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]扬州大学附属医院药学部,扬州225001 [2]山东省东阿县人民医院药学部,东阿252299 [3]延边大学药学院,延吉133002 [4]青岛大学附属医院药学部,青岛266003

出　　处：《医药导报》2025年第5期814-816,共3页Herald of Medicine

摘　　要：1例75岁初诊胃癌患者,行化学治疗联合纳武利尤单抗新辅助治疗2周期后反复发生乏力、意识模糊、低钠血症,后诊断为肾上腺皮质功能不全。应用糖皮质激素替代治疗后好转,但皮质醇一直低下,需长期服用糖皮质激素治疗。This report presents a case of a 75-year-old patient with newly diagnosed gastric cancer,who had repeated symptoms of fatigue,confusion,and hyponatremia after 2 cycles of chemotherapy combined with nivolumab as neoadjuvant treatment and was later diagnosed with adrenal cortical insufficiency.After applying corticosteroid replacement therapy,there was improvement,but cortisol remained low,and long-term corticosteroid therapy is needed.

关 键 词：纳武利尤单抗 免疫检查点抑制剂 肾上腺功能不全 药品不良反应 

分 类 号：R979[医药卫生—药品] R969[医药卫生—药学]