机构地区:[1]河南省郑州市第八人民医院,郑州市精神卫生中心,450013 [2]新乡医学院心理学院
出 处:《中国健康心理学杂志》2025年第5期661-669,共9页China Journal of Health Psychology
基 金:河南省医学科技攻关计划(编号:2018020866)。
摘 要:目的:探讨育龄期女性双相障碍躁狂发作患者共病高泌乳素血症的患病率及危险因素,为临床预防、治疗及改善生育能力提供依据。方法:选取2018年12月至2020年8月某院收治的入院时未服药的54例育龄期女性双相障碍躁狂发作患者为研究对象,分为正常泌乳素(Prolactin,PRL)组(29例)和高泌乳素血症(Hyperprolactinemia,HPRL)组(25例),比较两组的临床指标。用Spearman相关分析探讨PRL与各项临床指标的相关性。用Logistic回归分析明确HPRL发生的危险因素。结果:(1)育龄期女性躁狂发作住院患者HPRL的患病率为46.3%;(2)与正常PRL组相较,HPRL组的患者月经更不规律,腰围及BMI更低,游离甲状腺素(Free Thyroxine,FT4)及高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)均更高,差异均有统计学意义(P<0.05);(3)Spearman相关分析结果显示,PRL与FT4、HDL-C呈正相关(r=0.385,0.405;P<0.05),PRL与腰围、BMI呈负相关(r=-0.425,-0.408;P<0.05);(4)多元线性回归分析结果显示,PRL与严重躁狂症状呈正相关(B=12.044,P<0.05);(5)Logistic回归分析结果显示,月经越不规律,HPRL的患病风险越高(OR=0.130);FT4越高,HPRL的患病风险越高(OR=1.054),HDL-C越高,HPRL的患病风险越高(OR=1.635)。结论:育龄期女性躁狂发作住院患者HPRL的患病率46.3%,高于一般人群;月经不规律、高FT4及高HDL-C为患轻度HPRL的危险因素;轻度泌乳素水平升高对患者的体质量有保护作用,但会对生育能力及疾病严重程度产生不良影响。Objective:To explore the prevalence and risk factors of hyperprolactinemia(HPRL)comorbidity in reproductive-aged women with manic episodes of bipolar disorder,and to provide a basis for clinical prevention,treatment,and improvement of fertility.Methods:Fifty-four reproductive-aged women with manic episodes of bipolar disorder who were not taking medication upon admission to Zhengzhou Eighth People's Hospital from December 2018 to August 2020 were selected as the research subjects and divided into the normal prolactin(PRL)group(29 cases)and the HPRL group.The clinical indicators of the two groups were compared.Spearman correlation analysis was used to explore the correlations between PRL and various clinical indicators.Logistic regression analysis was used to determine the risk factors for the occurrence of HPRL.Results:①The prevalence of HPRL in hospitalized reproductive-aged women with manic episodes was 46.3%;②Compared with the normal PRL group,patients in the HPRL group had more irregular menstruation,lower waist circumference and body mass index(BMI),and higher free thyroxine(FT4)and high-density lipoprotein cholesterol(HDL-C),and the differences were statistically significant(P<0.05).③The results of Spearman correlation analysis showed that PRL was positively correlated with FT4 and HDL-C(r=0.385,0.405;P<0.05),and negatively correlated with waist circumference and BMI(r=-0.425,-0.408;P<0.05);④The results of multiple linear regression analysis showed that PRL was positively correlated with severe manic symptoms(B=12.044,P<0.05);⑤The results of Logistic regression analysis showed that the more irregular the menstruation,the higher the risk of HPRL(OR=0.130);The higher the FT4,the higher the risk of HPRL(OR=1.054),and the higher the HDL-C,the higher the risk of HPRL(OR=1.635).Conclusion:The prevalence of HPRL in hospitalized reproductive-aged women with manic episodes is 46.3%,which is higher than that in the general population.Irregular menstruation,high FT4,and high HDL-C are risk factors for mild H
关 键 词:高泌乳素血症 危险因素 生化指标 育龄期女性 躁狂发作
分 类 号:R395.4[哲学宗教—心理学] R749.05[医药卫生—医学心理学]
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