急性缺血性脑卒中急性期与恢复期抑郁发生的影响因素  

Analysis of influencing factors of depression in acute and recovery stages of acute ischemic stroke

作　　者：张灿飞[1] 赵薛斌 戚纪胜[1] ZHANG Canfei;ZHAO Xuebin;QI Jisheng(Department of Neurology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学第一附属医院神经内科,洛阳471003

出　　处：《中国健康心理学杂志》2025年第5期697-701,共5页China Journal of Health Psychology

基　　金：2024年度河南省医学科技攻关计划项目(编号:LHGJ20240419)。

摘　　要：目的:分析缺血性脑卒中急性期与恢复期抑郁发生的影响因素。方法:选取2021年8月-2023年12月某院住院或门诊随诊的527例缺血性脑卒中患者为研究对象。依据患者发病阶段的不同分为急性组(发病后第1个月内,281例)、恢复组(发病后第2~6个月,246例)。统计两组患者抑郁发生情况,并分为抑郁组和非抑郁组两个亚组。对比抑郁组和非抑郁组患者的临床资料。Logistic多因素回归分析影响缺血性脑卒中急性期与恢复期患者抑郁发生的危险因素。结果:恢复组抑郁发生率高于急性组(χ^(2)=6.416,P<0.05)。缺血性脑卒中急性期抑郁组女性占比、年龄及NIHSS评分高于非抑郁组(χ^(2)=7.553,t=6.899,12.860;P<0.05)。缺血性脑卒中恢复期抑郁组女性占比、年龄及NIHSS评分高于非抑郁组(χ^(2)=6.602,t=7.283,15.657;P<0.05)。Logistic多因素分析显示,年龄(OR:3.108,95%CI:1.882~5.134)、NIHSS评分(OR:3.449,95%CI:2.880~5.696)是影响急性期缺血性脑卒中患者抑郁发生的危险因素(P<0.05),年龄(OR:3.196,95%CI:1.966~5.197)、NIHSS评分(OR:3.611,95%CI:2.221~5.872)是影响恢复期缺血性脑卒中患者抑郁发生的危险因素(P<0.05)。结论:缺血性脑卒中急性期与恢复期患者抑郁的发生与年龄、神经功能缺损有关。Objective:To analyze the influencing factors of depression in acute stage and recovery stage of ischemic stroke.Methods:A total of 527 patients with ischemic stroke in our hospital from August 2021 to December 2023 were selected as the research object.Patients were divided into acute group(281 cases in the first month after onset)and recovery group(246 cases in the second to sixth months after onset)according to the different stages of onset.The incidence of depression in the two groups was counted,and the patients were divided into two subgroups according to whether they were depressed or not.The clinical data of patients with depression and non-depression were compared.Results:The incidence of depression and NIHSS score in the recovery group were higher than those in the acute group(χ^(2)=6.416,P<0.05).The proportion,age,and NIHSS score of women in the acute depression group of ischemic stroke were higher(χ^(2)=7.553,t=6.899,12.860;P<0.05).The proportion,age,and NIHSS scores of women in the depression group during the recovery period of ischemic stroke were higher than those in the non depression group(χ^(2)=6.602,t=7.283,15.657;P<0.05).Logistic multivariate analysis showed that age(OR:3.108,95%CI:1.882~5.134),NIHSS score(OR:3.449,95%CI:2.880~5.696)were risk factors for depression in acute ischemic stroke patients(P<0.05),while age(OR:3.196,95%CI:1.966~5.197),NIHSS score(OR:3.611,95%CI:2.221~5.872)were risk factors for depression in convalescent ischemic stroke patients(P<0.05).Conclusion:The occurrence of depression in patients with acute and convalescent ischemic stroke is related to age,neurological deficit.

关 键 词：缺血性脑卒中 急性期 恢复期 抑郁 临床特征 神经功能 

分 类 号：R395.2[哲学宗教—心理学]