项五针联合心理干预对脑卒中吞咽障碍患者吞咽功能、负面情绪及血清BDNF、NGF水平的影响  

Effect of five needles combined with psychological intervention on swallowing function,negative emotions,and serum BDNF and NGF levels in stroke patients with swallowing disorders

作　　者：邵庆敏 秦合伟 彭俊峰 SHAO Qingmin;QIN Hewei;PENG Junfeng(Department of Rehabilitation,Henan Provincial Hospital of Traditional Chinese Medicine(the Second Affiliated Hospital of Henan University of Traditional Chinese Medicine),Zhengzhou 450000,China)

机构地区：[1]河南省中医院(河南中医药大学第二附属医院)康复科,郑州450000

出　　处：《中国健康心理学杂志》2025年第5期732-737,共6页China Journal of Health Psychology

基　　金：2023年度河南省中医学“双一流”创建科学研究专项课题(编号:HSRP-DFCTCM-2023-3-27)。

摘　　要：目的:探讨项五针联合心理干预对脑卒中吞咽障碍患者吞咽功能、负面情绪及血清脑源性神经营养因子(BDNF)、神经生长因子(NGF)水平的影响。方法:选取某院在2022年6月—2023年10月收治的脑卒中吞咽障碍患者85例。随机将其分成对照组(43例)和观察组(42例)。对照组实施项五针治疗,观察组在对照组基础上实施心理干预治疗。比较两组吞咽功能[标准吞咽功能评定量表(SSA)]、洼田饮水试验评分、负面情绪[汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)]、血清BDNF和NGF水平、临床疗效及生活质量[健康状况评估量表(SF-36)]。结果:干预4周后,观察组SSA、洼田饮水试验、HAMA、HAMD评分均低于对照组(t=11.746,14.921,9.745,15.915;P<0.05);观察组血清BDNF、NGF水平均高于对照组(t=12.127,8.280;P<0.05);观察组总有效率高于对照组(χ^(2)=6.303;P<0.05);观察组SF-36各维度及总评分均高于对照组(t=8.200,11.694,6.454,10.133,8.852,7.944,7.692,12.583,17.816;P<0.05)。结论:项五针联合心理干预治疗脑卒中吞咽障碍患者疗效确切,可促进其吞咽功能恢复,改善负面情绪和血清神经营养因子水平,提高生活质量。Objective:To explore the effects of five needles combined with psychological intervention on swallowing function,negative emotions,and serum brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)levels in stroke patients with swallowing disorders.Methods:A total of 85 stroke patients with swallowing disorders admitted to our hospital from June 2022 to October 2023 were selected.Randomly divide them into a control group(43 cases)and an observation group(42 cases).The control group received five needle therapy,while the observation group received psychological intervention treatment on the basis of the control group.Compare swallowing function[standard swallowingfunction rating scale(SSA)],Wada drinking water test scores,negative emotions[hamilton anxiety scale(HAMA),hamilton depression scale(HAMD)],serum BDNF and NGF levels,clinical efficacy and quality of life[health status assessment scale(SF-36)]between two groups.Results:After 4 weeks of intervention,the scores of SSA,water swallow test,HAMA and HAMD in the observation group were lower(t=11.746,14.921,9.745,15.915;P<0.05).The levels of serum BDNF and NGF in the observation group were higher(t=12.127,8.280;P<0.05).The total effective rate of the observation group was higher(χ^(2)=6.303;P<0.05).The dimensions and total score of SF-36 in the observation group were higher(t=8.200,11.694,6.454,10.133,8.852,7.944,7.692,12.583,17.816;P<0.05).Conclusion:The combination of five needles combined with psychological intervention has a definite therapeutic effect on stroke patients with swallowing disorders,which can promote their swallowing function recovery,improve negative emotions and serum neurotrophic factor levels,and improve their quality of life.

关 键 词：脑卒中 吞咽障碍 项五针 心理干预 负面情绪 脑源性神经营养因子 

分 类 号：R395.5[哲学宗教—心理学] R749.92[医药卫生—医学心理学]