布鲁氏菌与宿主天然免疫信号通路相互作用的研究进展  

Progress on the Interactions of Brucella with Host Innate Immunity Signaling Pathways

作　　者：刘爱军[1] 黄晓兵[1] 张传亮[1] 张红丽[1] LIU Aijun;HUANG Xiaobing;ZHANG Chuanliang;ZHANG Hongli(Zhejiang Animal Disease Prevention and Control Center,Hangzhou 311119,China)

机构地区：[1]浙江省动物疫病预防控制中心,杭州311119

出　　处：《畜牧兽医学报》2025年第4期1561-1574,共14页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：浙江省三农九方科技协作计划项目(2024SNJF043)。

摘　　要：布鲁氏菌病(brucellosis)是一种由布鲁氏菌(Brucella)感染引起的全球性人兽共患病。近年来,我国布鲁氏菌病防控形势严峻,对牛羊养殖业和公共卫生安全构成较大威胁。天然免疫是抵御病原微生物感染的第一道防线,对维持机体的稳态至关重要。布鲁氏菌能够通过多种策略调节天然免疫信号通路,从而建立持续性感染,也能引起关节炎、肝炎、脑炎、流产等炎症性疾病。全面深入理解布鲁氏菌与天然免疫信号通路相互作用机制,可以为研发安全高效的疫苗或药物提供新的思路。因此,本文综述了Toll样受体(Toll-like receptors, TLRs)、环鸟苷酸腺苷酸合成酶(cyclic guanosine adenylate synthetase, cGAS)、干扰素基因刺激因子(stimulator of interferon genes, STING)、NOD样受体(NOD-like receptors, NLRs)、AIM2样受体(AIM2-like receptors, ALRs)、C型凝集素受体(C-type lectin receptors, CLRs)和RIG-I样受体(RIG-I-like receptors, RLRs)等天然免疫信号通路在抵御布鲁氏菌感染中的作用及机制,并总结了布鲁氏菌逃逸或劫持这些信号通路的策略。Brucellosis is a global zoonosis caused by Brucella infection.In recent years,the situation of brucellosis prevention and control is grim in China,posing a great threat to the cattle and sheep farming industry and public health security.Innate immunity serves as the first line of defense against pathogenic mocrobial infections and is crucial for maintaining homeostasis of the organism.Brucella can modulate innate immunity signaling pathways through a variety of strategies to establish persistent infections and also cause inflammatory diseases such as arthritis,hepatitis,encephalitis,and abortion.A comprehensive and in-depth understanding of the molecular mechanisms of Brucella interactions with innate immunity signaling pathways may provide new ideas for the development of safe and effective vaccines or drugs.Therefore,this paper reviews the roles and mechanisms of innate immunity signaling pathways such as Toll-like receptors(TLRs),cyclic guanosine adenylate synthetase(cGAS),stimulator of interferon genes(STING),NOD-like receptors(NLRs),AIM2-like receptors(ALRs),C-type lectin receptors(CLRs)and RIG-I-like receptors(RLRs)in the defense against Brucella infections,and summarizes the strat-egies of Brucella evade or hijacking these signaling pathways.

关 键 词：布鲁氏菌 免疫逃逸 Toll样受体 环鸟苷酸腺苷酸合成酶 干扰素基因刺激因子 NOD样受体 AIM2样受体 C型凝集素受体 RIG-I样受体 

分 类 号：S852.614[农业科学—基础兽医学]