金黄色葡萄球菌毒力调控及减毒药物研究进展  

Research Progress on Virulence Regulation and Antivirulence Drugs of Staphylococcus aureus

作　　者：吉星 李俊 王冉[1] 何涛[1] JI Xing;LI Jun;WANG Ran;HE Tao(Institute of Agricultural Product Safety and Nutrition/Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China)

机构地区：[1]江苏省农业科学院农产品质量安全与营养研究所/省部共建国家重点实验室培育基地江苏省食品质量安全重点实验室,南京210014

出　　处：《畜牧兽医学报》2025年第4期1594-1607,共14页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：江苏省自然科学基金项目(BK20220746)。

摘　　要：金黄色葡萄球菌是一种重要的人兽共患病原菌,可引起多种感染性疾病,严重威胁人类和动物健康。金黄色葡萄球菌可产生毒素、黏附蛋白和免疫逃逸因子等多种毒力因子,且具有复杂的毒力调控网络。由于传统的抗生素治疗面临细菌耐药性等问题,开发靶向减弱或消除金黄色葡萄球菌毒力的新型减毒药物成为抗菌药物研发的新方向。本文综述了目前关于金黄色葡萄球菌毒力调控及减毒药物研究的最新进展,为全面理解金黄色葡萄球菌的致病机制和进一步研发减毒药物提供参考和科学依据。Staphylococcus aureus(S.aureus)is an important zoonotic pathogen capable of causing various infectious diseases,posing a serious threat to human and animal health.It produces multiple virulence factors such as toxins,adhesion proteins,and immune evasion factors,and possesses a complex regulatory network for virulence.Due to issues like antibiotic resistance faced by traditional antibiotic treatments,the development of novel drugs aimed at reducing or eliminating the virulence of S.aureus has become a new direction in antimicrobial drug development.This article provides a comprehensive review of the latest advances in the regulation of S.aureus virulence and the development of antivirulence drugs,offering a reference and scientific basis for understanding the pathogenic mechanisms of S.aureus and further research on antivirulence drugs.

关 键 词：金黄色葡萄球菌 毒力 调控机制 减毒药物 

分 类 号：S852.611[农业科学—基础兽医学]