尼可地尔联合多巴酚丁胺注射液治疗急性左心衰竭患者的效果  

Effects of Nicorandil combined with Dobutamine injection in treatment of patients with acute left heart failure

作　　者：张志刚 ZHANG Zhigang(Emergency Department of the Fifth People’s Hospital of Anyang,Anyang 455000 Henan,China)

机构地区：[1]安阳市第五人民医院急诊科,河南安阳455000

出　　处：《中国民康医学》2025年第9期38-40,45,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察尼可地尔联合多巴酚丁胺注射液治疗急性左心衰竭(ALHF)患者的效果。方法:回顾性分析2022年3月至2024年1月该院收治的80例ALHF患者的临床资料,按照治疗方法不同将其分为对照组与观察组各40例。对照组采用多巴酚丁胺注射液治疗,观察组在对照组基础上联合尼可地尔治疗。比较两组临床疗效,治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、每搏输出量(SV)、左心室收缩末期内径(LVESD)]、血流动力学指标[平均肺动脉压(mPAP)、中心静脉压(CVP)、体循环血管阻力(SVR)、肺血管阻力(PVR)]、血清学指标[一氧化氮(NO)、N末端B型利钠肽原(NT-proBNP)、内皮素-1(ET-1)]水平,以及不良反应发生率。结果:观察组治疗总有效率为90.00%(36/40),高于对照组的72.50%(29/40),差异有统计学意义(P<0.05);治疗后,两组LVEDD、LVESD水平均低于治疗前,且观察组低于对照组,两组SV、LVEF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组SVR、mPAP、PVR、CVP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组NO水平均高于治疗前,且观察组高于对照组,两组NT-proBNP、ET-1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:尼可地尔联合多巴酚丁胺注射液治疗ALHF患者可提高治疗总有效率,改善心功能指标、血清学指标水平,以及降低血流动力学指标水平,效果优于单纯多巴酚丁胺注射液治疗。Objective:To observe effects of Nicorandil combined with Dobutamine injection in treatment of patients with acute left heart failure(ALHF).Methods:The clinical data of 80 patients with ALHF admitted to this hospital from March 2022 to January 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,40 cases in each group.The control group was treated with Dobutamine injection,while the observation group was treated with Nicorandil on the basis of that of the control group.The clinical efficacy,the levels of cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),stroke volume(SV),left ventricular end-systolic diameter(LVESD)],hemodynamic indexes[mean pulmonary artery pressure(mPAP),central venous pressure(CVP),systemic vascular resistance(SVR),pulmonary vascular resistance(PVR)]and serological indexes[nitric oxide(NO),N-terminal B-type natriuretic peptide(NT-proBNP),endothelin-1(ET-1)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.00%(36/40),which was higher than 72.50%(29/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVEDD and LVESD in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of SV and LVEF in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of SVR,mPAP,PVR and CVP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of NO in the two groups

关 键 词：急性左心衰竭 多巴酚丁胺 尼可地尔 心功能 血清学 血流动力学 不良反应 

分 类 号：R541.6[医药卫生—心血管疾病]