机构地区:[1]南阳医学高等专科学校第三附属医院普通内科,河南南阳473000
出 处:《中国民康医学》2025年第9期41-45,共5页Medical Journal of Chinese People’s Health
摘 要:目的:观察恩格列净治疗2型糖尿病(T2DM)伴心力衰竭患者的效果。方法:选取2021年2月至2023年9月该院收治的85例T2DM伴心力衰竭患者进行前瞻性研究,按照随机数字表法将其分为研究组43例与对照组42例。对照组采用常规治疗,研究组在对照组基础上采用恩格列净治疗,比较两组临床疗效,治疗前后糖代谢指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1C)]、心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)]、炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-ɑ(TNF-ɑ)、白细胞介素-6(IL-6)]、疾病特异性指标[N末端B型利钠肽原(NT-proBNP)、6 min步行试验(6MWT)距离]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.35%,高于对照组的78.57%,差异有统计学意义(P<0.05);治疗后,两组FPG、2hPG、HbA1C水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组LVESD、LVEDD水平均低于治疗前,且研究组低于对照组,两组LVEF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-6、TNF-α水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组NT-proBNP水平均低于治疗前,且研究组低于对照组,两组6MWT距离均长于治疗前,且研究组长于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上采用恩格列净治疗T2DM伴心力衰竭患者可提高治疗总有效率,延长6MWT距离,改善心功能指标和疾病特异性指标水平,以及降低糖代谢指标和炎性因子水平的效果优于单纯常规治疗。Objective:To observe effects of Empagliflozin in treatment of type 2 diabetes mellitus(T2DM)complicated with heart failure.Methods:A prospective study was conducted on 85 patients with T2DM and heart failure admitted to this hospital from February 2021 to September 2023.According to the random number table method,they were divided into study group(43 cases)and control group(42 cases).The control group was treated with conventional treatment,while the study group was treated with Empagliflozin on the basis of that of the control group.The clinical efficacy,the levels of glucose metabolism indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)],inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-ɑ(TNF-ɑ),interleukin-6(IL-6)]and diseasespecific indexes[N-terminal B-type natriuretic peptide(NT-proBNP),6-minute walking test(6 MWT)distance]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.35%,which was higher than 78.57%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FPG,2hPG and HbA1c in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of LVESD and LVEDD in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the LVEF levels of the two groups were lower than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6 and TNF-αin th
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