肾康注射液联合左卡尼汀治疗慢性肾衰竭患者的效果  

Effects of Shenkang injection combined with Levocarnitine in treatment of patients with chronic renal failure

作　　者：常岐岐 郭宁 CHANG Qiqi;GUO Ning(Department of Nephrology of Yuyang District People’s Hospital(Yulin Children’s Hospital),Yulin 719000 Shaanxi,China;Department of Internal Medicine PF Xi’an Weiyang Aikang Zhuoyue Health Examination Center,Xi’an 710021 Shaanxi,China)

机构地区：[1]榆林市榆阳区人民医院(榆林市儿童医院)肾内科,陕西榆林719000 [2]西安未央爱康卓悦健康体检中心内科,陕西西安710021

出　　处：《中国民康医学》2025年第9期53-55,59,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察肾康注射液联合左卡尼汀治疗慢性肾衰竭患者的效果。方法:选取2022年8月至2024年3月榆林市榆阳区人民医院(榆林市儿童医院)收治的100例慢性肾衰竭患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各50例。两组均进行血液透析,在此基础上,对照组予以左卡尼汀治疗,研究组在对照组基础上联合肾康注射液治疗。比较两组临床疗效,治疗前后中医证候积分、肾功能指标[血肌酐(Scr)、血尿素氮(BUN)]水平、炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)]水平,以及不良反应发生率。结果:研究组治疗总有效率为96.00%(48/50),高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);治疗后,两组恶心呕吐、身重困倦、纳呆、肢体麻木等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组Scr、BUN水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-1β、TNF-α水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肾康注射液联合左卡尼汀治疗慢性肾衰竭患者可提高治疗总有效率,降低中医证候积分和肾功能指标、炎性因子水平,效果优于单纯左卡尼汀治疗。Objective:To observe effects of Shenkang injection combined with Levocarnitine in treatment of patients with chronic renal failure.Methods:A prospective study was conducted on 100 patients with chronic renal failure admitted to Yulin Yuyang District People’s Hospital(Yulin Children’s Hospital)from August 2022 to March 2024.According to the random number table method,they were divided into study group and control group,50 cases in each group.Hemodialysis was performed in both groups.On this basis,the control group was treated with Levocarnitine,while the study group was treated with Shenkang injection on the basis of that of the control group.The clinical efficacies,the TCM syndrome scores,the levels of renal function indexes[serum creatinine(Scr),blood urea nitrogen(BUN)]and inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.00%(48/50),which was higher than 80.00%(40/50)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as nausea and vomiting,heavy body and sleepiness,anorexia and limb numbness in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of Scr and BUN in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-1βand TNF-αin the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence

关 键 词：肾康注射液 左卡尼汀 慢性肾衰竭 血液透析 肾功能 炎性因子 中医证候积分 

分 类 号：R692.5[医药卫生—泌尿科学]