贝利尤单抗治疗中重度系统性红斑狼疮患者的效果  

Effects of Belimumab in treatment of patients with moderate to severe systemic lupus erythematosus

作　　者：孙艳芬 周孝会 SUN Yanfen;ZHOU Xiaohui(Department of Nephrology of Guiyang International Hospital,Guiyang 550000 Guizhou,China)

机构地区：[1]贵黔国际医院肾内科,贵州贵阳550000

出　　处：《中国民康医学》2025年第9期70-72,76,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察贝利尤单抗治疗中重度系统性红斑狼疮(SLE)患者的效果。方法:选取2022年2月至2024年2月该院收治的78例SLE患者进行前瞻性研究,按随机数字表法将其分为对照组与研究组各39例。对照组采用醋酸泼尼松联合硫酸羟氯喹治疗,研究组在对照组基础上增加贝利尤单抗治疗,比较两组治疗前后疾病活动度[SLE活动性指数(SLEDAI)]评分、抗双链DNA抗体(ds-DNA)水平、免疫球蛋白[免疫球蛋白(Ig)A、IgG、IgM]水平、炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-17、IL-23]水平、补体水平和不良反应发生率。结果:治疗后,两组SLEDAI评分和抗ds-DNA水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IgA、IgG、IgM水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组hs-CRP、IL-17、IL-23水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组补体C3、C4水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:贝利尤单抗治疗中重度SLE患者可提高补体C3、C4水平,降低疾病活动度评分、抗ds-DNA水平、免疫球蛋白水平和炎性因子水平,效果优于醋酸泼尼松联合硫酸羟氯喹治疗。Objective:To observe effects of Belimumab in treatment of patients with moderate to severe systemic lupus erythematosus(SLE).Methods:A prospective study was conducted on 78 SLE patients admitted to this hospital from February 2022 to February 2024.According to the random number table method,they were divided into control group and study group,39 cases in each group.The control group was treated with Prednisone acetate combined with Hydroxychloroquine sulfate,while the study group was treated with Belimumab on the basis of that of the control group.The disease activity[SLE disease activity index(SLEDAI)]scores,the anti-double-stranded DNA antibody(ds-DNA)levels,the immunoglobulin[immunoglobulin(Ig)A,IgG,IgM]levels,the inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin(IL)-17,IL-23]levels,the complement levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the SLEDAI scores and the anti-ds-DNA levels of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IgA,IgG and IgM in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP,IL-17 and IL-23 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of complement C3 and C4 in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P

关 键 词：系统性红斑狼疮 贝利尤单抗 醋酸泼尼松 硫酸羟氯喹 疾病活动度 免疫球蛋白 炎性因子 

分 类 号：R593.24[医药卫生—内科学]