血凝酶联合缩宫素治疗宫缩乏力性产后出血患者的效果  

Effects of Hemocoagulase combined with Oxytocin in treatment of patients with postpartum hemorrhage due to uterine inertia

作　　者：宋雪敏 SONG Xuemin(Department of Obstetrics and Gynecology of Yucheng County People’s Hospital,Shangqiu 476300 Henan,China)

机构地区：[1]虞城县人民医院妇产科,河南商丘476300

出　　处：《中国民康医学》2025年第9期77-79,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血凝酶联合缩宫素治疗宫缩乏力性产后出血患者的效果。方法:回顾性分析2021年1月至2024年4月该院收治的95例宫缩乏力性产后出血患者的临床资料,依据治疗方法不同将其分为对照组49例和观察组46例。对照组予以缩宫素治疗,观察组在对照组基础上联合血凝酶治疗。比较两组止血时间,用药后10、20、30 min宫腔压力水平,用药前后血管舒张因子[一氧化氮(NO)、一氧化氮合酶(NOS)、B型利钠肽(BNP)]、凝血功能指标[凝血酶原时间(PT)、D-二聚体(D-D)、纤维蛋白原(FIB)]水平,以及不良反应发生率。结果:观察组止血时间短于对照组,差异有统计学意义(P<0.05);用药后10、20、30 min,观察组宫腔压力水平均高于对照组,差异有统计学意义(P<0.05);用药后,两组NO、NOS、BNP水平均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05);用药后,两组PT均短于用药前,且观察组短于对照组,两组D-D、FIB水平均高于用药前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血凝酶联合缩宫素治疗宫缩乏力性产后出血患者可缩短止血时间,提高宫腔压力水平,改善凝血功能指标水平,降低血管舒张因子水平,效果优于单纯缩宫素治疗。Objective:To observe effects of Hemocoagulase combined with Oxytocin in treatment of patients with postpartum hemorrhage due to uterine inertia.Methods:The clinical data of 95 patients with postpartum hemorrhage due to uterine inertia admitted to this hospital from January 2021 to April 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group(49 cases)and observation group(46 cases).The control group was treated with Oxytocin,while the observation group was treated with Hemocoagulase on the basis of that of the control group.The hemostasis time,the intrauterine pressures 10,20 and 30 min after medication,the levels of vasodilation factors[nitric oxide(NO),nitric oxide synthase(NOS),B-type natriuretic peptide(BNP)]and coagulation function indexes[prothrombin time(PT),D-dimer(D-D),fibrinogen(FIB)]before and after medication,and the incidence of adverse reactions were compared between the two groups.Results:The hemostasis time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).10,20 and 30 min after medication,the intrauterine pressure levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After medication,the levels of NO,NOS and BNP in the two groups were lower than those before medication,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After medication,the PT of the two groups were shorter than those before medication,and that in the observation group was shorter than that in the control group;the levels of D-D and FIB in the two groups were higher than those before medication,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).

关 键 词：宫缩乏力 产后出血 血凝酶 缩宫素 宫腔压力 血管舒张 凝血功能 

分 类 号：R714.461[医药卫生—妇产科学]