富血小板血浆与透明质酸钠关节腔内注射治疗膝骨关节炎术后患者的效果比较  

Comparison of effects of intra-articular injection of platelet-rich plasma and Sodium hyaluronate in treatment of postoperative patients with knee osteoarthritis

作　　者：王伟 郑晓琳 WANG Wei;ZHENG Xiaolin(Department of General Surgery of Zibo Municipal Government Hospital,Zibo 255000 Shandong,China)

机构地区：[1]淄博市市级机关医院普外科,山东淄博255000

出　　处：《中国民康医学》2025年第9期151-153,157,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较富血小板血浆与透明质酸钠关节腔内注射治疗膝骨关节炎术后患者的效果。方法:回顾性分析2022年1月至2024年1月于该院进行胫骨高位截骨术和关节镜清理术治疗的80例膝骨关节炎患者的临床资料,根据术后治疗方案不同将其分为对照组和观察组各40例。对照组采用透明质酸钠关节腔内注射治疗,观察组采用富血小板血浆关节腔内注射治疗,比较两组临床疗效,治疗前后血清学指标[前列腺素E2(PGE2)、骨保护素(OPG)、诱生型一氧化氮合酶(iNOS)、白细胞介素-1β(IL-1β)]水平、膝关节功能[膝关节主观功能评分表(IKDC)]评分,以及并发症发生率。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,两组PGE2、iNOS、IL-1β水平均低于治疗前,且观察组低于对照组,两组OPG水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后1、3个月,两组IKDC评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:富血小板血浆关节腔内注射治疗膝骨关节炎术后患者可提高治疗总有效率和膝关节功能评分,改善血清学指标水平,效果优于透明质酸钠关节腔内注射治疗。Objective:To compare effects of intra-articular injection of platelet rich plasma and Sodium hyaluronate in treatment of postoperative patients with knee osteoarthritis.Methods:The clinical data of 80 patients with knee osteoarthritis who underwent high tibial osteotomy and arthroscopic debridement in this hospital from January 2022 to January 2024 were retrospectively analyzed.According to different postoperative treatment schemes,they were divided into control group and observation group,40 cases in each group.The control group was treated with intra-articular injection of Hyaluronic acid,while the observation group was treated with intra-articular injection of platelet-rich plasma.The clinical efficacy,the serological indexes[prostaglandin E2(PGE2),osteoprotegerin(OPG),inducible nitric oxide synthase(iNOS),interleukin-1β(IL-1β)]levels and the knee joint function[international knee documentation committee(IKDC)]scores before and after the treatment,and the incidence of complications were compared between the two groups.Results:The total effective rate of the observation group was 95.00%(38/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PGE2,iNOS and IL-1βin the two groups were lower than those before the treatment,and those in the observation group were lower than the those in control group;the OPG levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).At 1 and 3 months after the treatment,the IKDC scores of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Intra-articular injection of platelet rich plas

关 键 词：富血小板血浆 透明质酸钠 关节腔内注射 膝骨关节炎 膝关节功能 

分 类 号：R684.3[医药卫生—骨科学]