氧杂双环[2.2.1]桥环骨架构建方法的研究进展  

Progress on Construction Method of Oxygen Heterocyclic Double Ring[2.2.1]Bridge Ring Skeleton

作　　者：梅春祥 刘钊 何述钟 MEI Chunxiang;LIU Zhao;HE Shuzhong(School of Pharmacy,Guizhou University,Guiyang 550025,China;Guizhou Provincial Synthetic Drug Engineering Laboratory,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州省合成药物工程实验室,贵州贵阳550025

出　　处：《广州化学》2025年第2期33-38,I0002,共7页Guangzhou Chemistry

基　　金：贵州省基础研究(自然科学)项目(ZK[2021]039)。

摘　　要：简单介绍了氧杂双环[2.2.1]桥环的结构及含其结构的天然产物,具体介绍了近年来氧杂双环[2.2.1]桥环骨架构建的各种方法,其中包括以取代的环氧化合物为前体合成、有机汞化合物诱导的自由基反应构建、Prins串联环化构建、金属路易斯酸催化(三氟甲磺酸铋、过渡金属)的串联反应构建、TMM的环加成反应构建等。各方法都存在各自的优缺点,本文就近年来氧杂双环[2.2.1]桥环构建的各种方法进行了总结,并展望了未来氧杂双环[2.2.1]桥环的构建方法改进方向。This article provides a brief introduction to the structure of the oxygen heterocyclic[2.2.1]bridge ring and its natural products.It specifically introduces various methods for constructing the framework of the oxygen heterocyclic[2.2.1]bridge ring in recent years,including the synthesis of substituted epoxy compounds as precursors,the construction of free radical reactions induced by organic mercury compounds,the construction of Prins tandem cyclization,the construction of metal Lewis acid catalyzed(bismuth trifluoromethanesulfonate,transition metals)tandem reactions,and the construction of TMM cycloaddition reactions.Each method has its own shortcomings.This article summarizes various methods for constructing oxygen heterocyclic[2.2.1]bridge rings in recent years,and looks forward to the improvement direction of future methods for constructing oxygen heterocyclic[2.2.1]bridge rings.

关 键 词：氧杂双环[2.2.1] 串联环化 金属催化 构建方法 

分 类 号：R978[医药卫生—药品]