PS-b-PEO本体自组装制备聚合物立方体及生物应用  

Preparation and Biological Application of Polymer Cubes by PS-b-PEO Self-assembly

作　　者：刘晓 时绪智 吴亭亭 党柯清 苏晓丹 LIU Xiao;SHI Xuzhi;WU Tingting;DANG Keqing;SU Xiaodan(School of Materials Science&Engineering,Nanjing University of Posts and Telecommunications,Nanjing 210023,China;School of Media and Arts,Nanjing University of Posts and Telecommunications,Nanjing 210023,China)

机构地区：[1]南京邮电大学材料科学与工程学院,江苏南京210023 [2]南京邮电大学传媒与艺术学院,江苏南京210023

出　　处：《广州化学》2025年第2期66-70,I0003,共6页Guangzhou Chemistry

基　　金：国家自然科学基金(2227050630)。

摘　　要：利用两亲性嵌段共聚物PS637-b-PEO161为模板,结合微流控技术,实现了聚合物立方体(polymer cubosome,PC)的连续制备。扫描电子显微镜(SEM)和透射电子显微镜(TEM)结果显示PC球面上呈现有序的孔道结构,聚焦离子束扫描电子显微镜(FIB)切片结果显示PC具有丰富的孔道结构,荧光共聚焦显微镜(LSCM)结果显示PCs对牛血清白蛋白(BSA)有较高的吸附能力,细胞毒性实验表明该材料有良好的生物相容性。Using amphiphilic block copolymer PS637-b-PEO161 as a template and combined with microfluidic technology,the continuous preparation of ordered polymer cubes(PCs)was achieved.The results of scanning electron microscopy(SEM)and transmission electron microscopy(TEM)showed an ordered pore structure on the spherical surface of PCs.The sectioning results of focused ion beam scanning electron microscopy(FIB)showed that PCs have rich pore structures.The fluorescence confocal microscopy(LSCM)results showed that PCs had significant adsorption capacity for bovine serum albumin(BSA).Cytotoxicity experiments have shown that the material has good biocompatibility.

关 键 词：嵌段共聚物 自组装 微流控 聚合物立方体 

分 类 号：O63[理学—高分子化学]