中医药改善糖尿病肾脏疾病间质纤维化的作用机制研究现状  

Current research status on mechanism of action of traditional Chinese medicine in improving interstitial fibrosis of diabetes kidney disease

作　　者：严佳怡 马骏[2] 钟逸斐[1] 张先闻[1] YAN Jiayi;MA Jun;ZHONG Yifei;ZHANG Xianwen(Department of Nephrology 1,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Nephrology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海中医药大学附属龙华医院肾病一科,上海200032 [2]上海交通大学医学院附属瑞金医院肾脏科,上海200025

出　　处：《内科理论与实践》2025年第1期38-45,共8页Journal of Internal Medicine Concepts & Practice

基　　金：国家自然科学基金项目(82274451);上海市“科技创新行动计划”(23Y11921400)。

摘　　要：糖尿病肾脏疾病(diabetic kidney disease,DKD)是由高血糖所致的慢性肾脏疾病,属于糖尿病常见的微血管并发症之一。间质纤维化作为其显著病理特征,是导致肾功能损伤的关键因素,其病理演变涉及代谢异常、血流动力学紊乱、炎症反应、细胞信号通路激活、表观遗传调控和细胞自噬等多重机制。本文通过检索多个数据库(Pubmed、Web of Science、中国知网、万方、维普等),对中医药改善DKD间质纤维化的作用机制相关文献进行整理分析。研究提示中医药可能通过多成分、多靶点、多途径延缓DKD间质纤维化。随着对DKD间质纤维化发病机制的进一步深入研究和中医药作用机制的不断阐明,中医药有望为DKD的防治提供更有效的策略。Diabetes kidney disease(DKD)is a chronic kidney disease caused by hyperglycemia,which is one of the common microvascular complications of diabetes.As one of the significant pathological features,interstitial fibrosis is a key factor leading to renal dysfunction.Its pathological evolution involves multiple mechanisms such as metabolic abnormalities,hemodynamic disorders,inflammatory responses,activation of cellular signaling pathways,epigenetic regulation,and cellular autophagy.This article sorted and analyzed the relevant research on the mechanism of action of traditional Chinese medicine(TCM)in improving interstitial fibrosis of DKD through searching multiple databases(Pubmed,Web of Science,CNKI,WANFANG,VIP databases,etc.).Studies have shown that treatment of TCM may delay DKD interstitial fibrosis through its multi-component,multi-target and multi pathway.In the future,with further in-depth research on the pathogenesis of DKD interstitial fibrosis and continuous clarification of the mechanism of action of TCM,TCM is expected to provide more effective strategies for the prevention and treatment of DKD.

关 键 词：糖尿病肾脏疾病 间质纤维化 中医药 

分 类 号：R587[医药卫生—内分泌]