心房颤动与miRNA-21之间的相关性研究  

Study on the correlation between atrial fibrillation and miRNA-21

作　　者：陈旭[1] 张志宇 杨博 任飞霏 李广平[4] CHEN Xu;ZHANG Zhiyu;YANG Bo;REN Feifei;LI Guangping(Department of Cardiology,Beichen Hospital of Nankai University,Tianjin 300400,China;Tianjin Beichen District Center for Disease Control and Prevention;Beijing Garrison District Dongcheng Third Retired Cadre Rest and Rehabilitation Center;The Second Hospital of Tianjin Medical University)

机构地区：[1]南开大学附属北辰医院心内科,天津300400 [2]天津市北辰区疾病预防控制中心 [3]北京卫戍区东城第三离职干部休养所 [4]天津医科大学第二医院

出　　处：《包头医学院学报》2025年第4期50-54,85,共6页Journal of Baotou Medical College

基　　金：天津市北辰区科技计划项目(SHGY-2021018)。

摘　　要：目的:通过临床资料研究心房颤动(AF)与微小非编码RNA-21(miRNA-21)之间的相关性,以期为临床AF的诊治提供参考价值。方法:收集2022年09月至2023年12月在天津市某三甲医院心内科住院的患者142例,其中十二导联体表心电图的结果满足“P波消失,代之以大小不等、形态各异的小f波,RR间期绝对不规则”条件的纳入AF组,70例,其余72例纳入对照组,比较两组患者之间的血浆miRNA-21及心脏超声等各项指标。结果:与对照组比较,AF组利伐沙班、达比加群酯、华法林等抗凝药物以及胺碘酮用药量明显多于对照组(P<0.05),低密度脂蛋白胆固醇(LDLc)结果相对低(P<0.05),左房内径较大(P<0.05),血浆中miRNA-21高表达(P<0.05)。Logistic回归分析结果显示AF的发生与左房内径、miRNA-21指标有关(P<0.05)。结论:AF的发生可能与血浆中miRNA-21表达和左房内径大小存在相关性。Objective:To study the correlation between atrial fibrillation(AF)and micro RNA-21(miRNA-21)through clinical data,in order to provide reference value for clinical diagnosis and treatment of AF.Methods:A total of 142 patients who were hospitalized in the Department of Cardiology of a tertiary hospital in Tianjin from September 2022 to December 2023 were collected.According to the results of 12-lead surface electrocardiogram,70 patients who met the conditions of'P wave disappeared,replaced by small f waves of different sizes and shapes,and RR interval was absolutely irregular'were included in the AF group,and the remaining 72 patients were included in the control group.Plasma miRNA-21 and echocardiography were compared between the two groups.Results:Compared with the control group,the dosage of anticoagulants such as rivaroxaban,dabigatran etexilate,warfarin and amiodarone in AF group was significantly higher than that in control group(P<0.05),the level of low density lipoprotein cholesterol(LDLc)was lower(P<0.05),the diameter of left atrium was larger(P<0.05),and the expression of miRNA-21 in plasma was higher(P<0.05).Logistic regression analysis showed that the occurrence of AF was related to left atrial diameter and miRNA-21 indexes(P<0.05).Conclusion:The occurrence of AF may be correlated with the expression of miRNA-21 in plasma and the size of left atrium.

关 键 词：心房颤动 微小非编码RNA-21 左房内径 血浆 

分 类 号：R541.7[医药卫生—心血管疾病]