寻常型银屑病中医证候演变规律的文献数据分析  

Literature Data Analysis on the Evolution Pattern of Traditional Chinese Medicine Syndromes in Psoriasis Vulgaris

作　　者：官科汶 谢秀丽 卢传坚 GUAN Kewen;XIE Xiuli;LU Chuanjian(The Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou,510405;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Traditional Chinese Medical/Guangdong Academy of Traditional Chinese Medicine;State Key Laboratory of Dampness Syndrome of Traditional Chinese Medicine)

机构地区：[1]广州中医药大学第二临床医学院,广东省广州市510405 [2]广州中医药大学第二附属医院/广东省中医院/广东省中医药科学院 [3]省部共建中医湿证国家重点实验室

出　　处：《中医杂志》2025年第8期834-840,共7页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(U23A6012,U20A20397);省部共建中医湿证国家重点实验室项目(SZ2021ZZ0201);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202204);广州市科技计划(2024A03J0726)。

摘　　要：目的基于文献数据探析寻常型银屑病(PV)中医证候、证素分布情况及其演变规律。方法检索中国知网(CNKI)、万方数据知识服务平台(Wanfang)、维普中文科技期刊数据库(VIP)、中国生物医学文献服务系统(CBM)以及PubMed、Embase、Web of Science数据库中公开发表的,从建库到2023年12月31日的PV中医证候相关文献。对纳入文献中PV中医证候和证素分布进行统计分析,并按自然年5年一组进行分期,进一步总结分析不同时期中医证候和证素动态演变规律。结果最终筛选纳入文献2853篇,证候出现5896次,PV常见证候有血热证2167次(36.75%),血瘀证1219次(20.68%),血燥证1124次(19.06%),湿热证263次(4.46%)等,常见证候分类有血证类4680次(79.38%)、湿证类347次(5.89%)等,常见病位证素有血分4874次(94.38%)、脾99次(1.92%)等,常见病性证素有血热2213次(25.96%)、血燥1434次(16.82%)、血瘀1330次(15.60%)等。PV的中医证候中,除1978-1983年外,血热证、血瘀证、血燥证三者均占前三,且其占比之和呈总体上升趋势(从67.65%到81.69%),脾虚湿阻证占比呈总体上升趋势(从0.24%到1.46%);证候分类方面,血证类占比呈总体上升趋势(从67.65%到83.46%),各时期占比均为首位。湿证类占比呈大致下降趋势(从17.65%到4.54%),但除1994-1998年、1999-2003年外,其在各时期占比均仅次于血证类。脾系证类占比呈总体上升趋势(从0.24%到1.85%);病位证素血分的占比在各时期均稳定在90%以上,脾的占比大致呈上升趋势(从0.68%到3.23%);病性证素血热(从19.23%到33.27%)、血瘀(从1.92%到20.83%)占比总体呈较大幅度的上升趋势。湿的占比总体呈先下降后小幅度上升趋势(从11.54%到5.73%)。结论在PV中医证候分布中,血热证、血瘀证、血燥证最常见,证候分类以血证类为主,病位证素多在血分,病性证素以血热、血瘀、血燥突出。演变规律显示,血热证、血瘀证、血燥证长期居于前位且�Objective To explore the distribution and evolution patterns of traditional Chinese medicine(TCM)syndromes and syndrome elements in psoriasis vulgaris(PV).Methods Literature related to TCM syndromes of PV published in databases including China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform(Wanfang),VIP Chinese Technology Periodical Database(VIP),Chinese Biomedical Literature Database(CBM),PubMed,Embase,and Web of Science from their inception to December 31,2023,was retrieved.Statistical analysis was conducted on the distribution of TCM syndromes and syndrome elements in the included studies.The data were further categorized into five-year periods to analyze the dynamic changes in syndromes and syndrome elements over time.Results A total of 2853 studies were included,with 5896 syndrome occurrences.The most common TCM syndromes in PV were blood-heat syndrome(2167 occurrences,36.75%),blood-stasis syndrome(1219 occurrences,20.68%),blood-dryness syndrome(1124 occurrences,19.06%),and damp-heat syndrome(263 occurrences,4.46%).The most frequent syndrome categories included blood syndromes(4680 occurrences,79.38%)and dampness syndromes(347 occurrences,5.89%).The most common syndrome elements related to disease location were blood division(4874 occurrences,94.38%)and spleen(99 occurrences,1.92%).The most common syndrome elements related to disease nature were blood-heat(2213 occurrences,25.96%),blood-dryness(1434 occurrences,16.82%),and blood-stasis(1330 occurrences,15.60%).Except for the period 1978-1983,blood-heat,blood-stasis,and blood-dryness syndromes consistently ranked among the top three,with their combined proportion showing an overall upward trend(from 67.65%to 81.69%).The proportion of spleen deficiency with damp obstruction syndrome also increased(from 0.24%to 1.46%).In terms of syndrome classification,the proportion of blood syndromes showed an overall upward trend(from 67.65%to 83.46%),ranking first in all periods.The proportion of dampness syndromes showed a general downward

关 键 词：寻常型银屑病 中医证候 证素 文献研究 

分 类 号：R275.9[医药卫生—中西医结合]