不同糖代谢状态人群中医证候积分与脂肪偏好的相关性研究  

Correlational Study on TCM Syndrome Integrals and Fat Preference among People with Different Sugar Metabolism Status

作　　者：刘德亮[1] 张鹏翔 曾霖 楚淑芳[1] 李惠林[1] 曾子文 LIU Deliang;ZHANG Pengxiang;ZENG Lin;CHU Shufang;LI Huilin;ZENG Ziwen(Shenzhen Traditional Chinese Medicine Hospital/Forth Clinical Medical School,Guangzhou University of Chinese Medicine,Shenzhen 518033,China;Health Service Center of Tongle Community,Longgang District Central Hospital,Shenzhen 518116,China)

机构地区：[1]深圳市中医院/广州中医药大学第四临床医学院,广东深圳518033 [2]龙岗区中心医院同乐社区健康服务中心,广东深圳518116

出　　处：《西部中医药》2025年第4期27-32,共6页Western Journal of Traditional Chinese Medicine

基　　金：广东省基础与应用基础研究项目(2021A1515220177);深圳市科技计划基础研究专项自然科学基金(JCYJ20210324111212033);国家自然科学基金(81704002);深圳市医疗卫生“三名工程”项目(SZSM201512043)。

摘　　要：目的:探究不同糖代谢状态人群脂肪偏好的变化及其和中医证候积分的相关性。方法:选取健康受试者、已确诊糖尿病前期患者、已确诊2型糖尿病患者各60例,计算中医证候积分;检测不同受试者脂肪敏感性,并调查饮食行为;检测空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)、总胆固醇(total cholesterol,TC)、总甘油三酯(total triglycerides,TG)、可溶性白细胞分化抗原36(soluble cluster of differentiation 36,sCD36);分析脂肪敏感性和中医证候积分及各生化指标之间的相关性。结果:2型糖尿病组阴虚热盛证证候积分、脂肪酸阈值、HbA1c、FPG、TC、sCD36均高于其他两组(P<0.05),而含脂食物感知排序任务得分低于其他两组;饮食喜好问卷调查结果提示不同糖代谢状态人群的口味偏好、高脂饮食摄入频次、对高脂饮食的喜好程度存在差异(P<0.05);相关性分析结果提示脂肪敏感性与证候积分、HbA1c、FPG、TC、TG、sCD36、饮食摄入量、高脂饮食摄入频次均存在相关性(P<0.05)。结论:不同糖代谢状态人群脂肪敏感性存在差异,且与中医证候积分存在相关性。Objective:To survey the changes in fat preference among people in different sugar metabolism status,and its connections with TCM syndrome integrals.Methods:Sixty health volunteers,sixty patients confirmed with prediabetes and another sixty patients with type 2 diabetes mellitus(T2DM)were selected to calculate TCM syndrome integrals;to detect fat sensitivity in different subjects and to investigate dietary behavior;to detect FPG,HbA1c,TC,TG and sCD36;to analyze the correlations between fat sensitivity,TCM syndrome integrals and different biochemical indexes.Results:T2DM group was higher than the other two groups in Yin deficiency and excessive heat pattern,fatty acid threshold,HbA1c,FPG,TC and sCD36(P<0.05),while lower than the other two groups in the scores for lipid-containing food perception sequencing task;the results of dietary preferences questionnaire survey suggested that the difference existed in the flavor preference,the frequency of high-fat diet intake and the fondness for high-fat diet among the population with different sugar metabolism status(P<0.05);correlational analysis results indicated that the correlation existed between fat sensitivity and syndrome scores,HbA1c,FPG,TC,TG,sCD36,dietary intake,and frequency of high-fat diet(P<0.05).Conclusion:Fat sensitivity is different among population with different sugar metabolism status,and it is related to TCM syndrome integrals.

关 键 词：糖尿病 阴虚热盛证 脂肪敏感性 饮食偏好 可溶性CD36 

分 类 号：R255.4[医药卫生—中医内科学]