基于数据挖掘的银屑病伴焦虑抑郁状态的用药规律探究  

Data Mining-based Discussion on the Medication Rules of Psoriasis with Anxiety and Depression

作　　者：仪凡 王晓旭 赵子慧 金琦 张广中[3] YI Fan;WANG Xiaoxu;ZHAO Zihui;JIN Qi;ZHANG Guangzhong(Affiliated Hospital to Shandong University of Traditional Chinese Medicine,Jinan 250014,China;First Clinical Medical School,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Beijing Hospital of TCM Affiliated to Capital Medical University,Beijing 100010,China)

机构地区：[1]山东中医药大学附属医院,山东济南250014 [2]山东中医药大学第一临床医学院,山东济南250014 [3]首都医科大学附属北京中医医院,北京100010

出　　处：《西部中医药》2025年第4期41-46,共6页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81974572,82274523)。

摘　　要：目的:利用数据挖掘技术探究中药治疗银屑病伴焦虑抑郁状态的用药规律,为银屑病伴焦虑抑郁状态的临床治疗提供一定参考。方法:以中国知网、万方、维普数据库收录的文献为资料来源,使用Excel 2019、SPSS Modeler 18.0、SPSS Statistics 20.0等软件对符合纳入标准的中药复方进行频次统计、关联规则分析、系统聚类分析等。结果:共纳入方剂60首,包含药物120味,药性以寒、温、平多见,药味以苦、甘、辛为主,多归肝、肺经;高频中药前10位为生地黄、柴胡、甘草、当归、牡丹皮、土茯苓、紫草、白芍、白鲜皮、黄芩,功效类型主要为清热药和补虚药;关联分析显示常见配伍为生地黄-党参、柴胡-栀子、柴胡-郁金、生地黄-丹皮-柴胡、柴胡-党参-生地黄、黄芩-栀子-柴胡;聚类分析发现从血论治银屑病药物分为3类聚类效果较好。结论:中药论治银屑病伴焦虑抑郁状态以清热凉血、疏肝解郁、养血解毒为治疗大法,初步明确了中药论治银屑病伴焦虑抑郁状态的用药规律,为临床用药及新处方研发提供了一定参考依据。Objective:To explore the medication rules of traditional Chinese medicine in the treatment of psoriasis with anxiety and depression using data mining technology,so as to provider certain reference for clinical therapy of the disease.Methods:CNKI,Wanfang and VIP were chosen as the source of the data,Excel 2019,SPSS Modeler 18.0 and SPSS Statistics 20.0 and other softwares were applied to perform frequency statistics,association rule analysis and system clustering analysis of herbal compounds that met the inclusion criteria.Results:Sixty prescriptions were included,containing 120 herbs,mostly of cold,warm and neutral nature,with the flavors of mainly bitter,sweet and pungent,and most entering the meridians of liver and lung.The top ten high-frequency herbs were Dihuang(Rehmanniae radix),Chaihu(Bupleuri Radix),and Gancao(Glycyrrhizae radix et rhizoma),Danggui(Angelicae sinensis radix),Mudanpi(Moutan cortex),Tufuling(Smilacis glabrae rhizoma),Zicao(Arnebiae radix),Baishao(Paeoniae radix alba),Baixianpi(Dictamni cortex),and Huangqin(Scutellariae radix),and they were the ones of clearing heat and tonifying;the analysis of association rules displayed that the common combinations were Dihuang-Dangshen(Codonopsis radix),Chaihu-Zhizi(Gardeniae fructus),Chaihu-Yujin(Curcumae radix),Dihuang-Mudanpi-Chaihu,Chaihu-Dangshen-Dihuang,and Huangqin-Zhizi-Chaihu;cluster analysis displayed that the drugs for treating psoriasis from blood were divided into three categories and the results had good clustering effects.Conclusion:The treatment for psoriasis with anxiety and depression mainly adopts clearing heat and cooling blood,soothing liver for relieving Qi stagnation,nourishing blood and detoxification as the therapeutic methods,and the study has primarily surveyed the medication rules of the treatment,which could provide certain reference for clinical application of herbs and research&development of new prescriptions.

关 键 词：银屑病 焦虑抑郁状态 数据挖掘 关联分析 用药规律 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]