基于关联和聚类分析探索中药治疗伊立替康迟发性腹泻的用药规律  

Exploration into the Medication Rules of Herbal Treatment for Delayed Diarrhea Induced by Irinotecan Based on Association Rules and Cluster Analysis

作　　者：何亚琳 马慧淼 王玉坤 程志强[2] HE Yalin;MA Huimiao;WANG Yukun;CHENG Zhiqiang(Beijing University of Chinese Medicine,Beijing 100029,China;China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院,北京100029

出　　处：《西部中医药》2025年第4期65-69,共5页Western Journal of Traditional Chinese Medicine

基　　金：北京市自然科学基金(7212194)。

摘　　要：目的:整理分析中药治疗伊立替康(irinotecan,CPT-11)迟发性腹泻的用药规律,为进一步指导临床用药提供理论依据。方法:检索中国期刊全文数据库(CNKI)、万方数据知识服务平台、维普数据库、PubMed收录的中药内服治疗CPT-11迟发性腹泻文献,筛选并统计符合纳入标准的中药处方,对中药频次、药性、药味、归经等进行分析,并采用关联规则分析和聚类分析等数据挖掘方法进行用药规律探索。结果:共纳入55首中药处方,涉及中药98味,总共出现频次532次。使用频次较高的中药为甘草、白术、茯苓、薏苡仁、党参;药性以温平为主,出现频次最高的是甘味,其次为苦味和辛味,归经以脾经、肺经、胃经为主;药物功效使用频率前5类为补气药、利水消肿药、清热燥湿药、温里药和敛肺涩肠药;对高频中药进行关联和聚类分析,可形成3个聚类方;关联规则中支持度较高的为健脾益气常用药物组合。结论:基于关联规则和系统聚类分析,中药治疗CPT-11迟发性腹泻以补气健脾为主,兼以利水渗湿、清热燥湿、温补中焦和收敛固涩之品。Objective:To provide theoretical reference for further guidance of clinical medication by analyzing the medication rules of herbal treatment for delayed diarrhea induced by irinotecan.Methods:The herbal prescriptions that met the inclusion criteria were screened and counted by searching the literature on oral administration of herbs in the treatment of delayed diarrhea induced by irinotecan from CNKI,Wanfang,VIP and PubMed,so as to analyze the frequency,the nature,the flavor and meridian tropism of the herbs,meanwhile,association rules and cluster analysis were applied to unearth the medication rules.Results:All 55 herbal prescriptions were included in the study,involving 98 herbs,and appearing 532 times in total.More frequently used herbs contained Gancao(Glycyrrhizae radix et rhizoma),Baizhu(Atractylodes macrocephala Koidz.),Fuling[Poria cocos(Schw.)Wol],Yiyiren(Coicis semen)and Dangshen(Codonopsis radix);.the drugs were mainly warm and flat,sweet appearing in the highest frequency,bitter and acrid the next,these drugs belonged to the meridians of spleen,lung and stomach;in the terms of efficacy,the top five categories were the ones of benefiting Qi,the ones of inducing diuresis to alleviate edema,the ones of clearing heat and drying dampness,the ones of warming the interior,the ones of constricting lung and the intestine;three clustering prescriptions were yielded through association rules and cluster analysis of high-frequency herbs;the results of association rules displayed that the commonly-used drug combination for invigorating spleen and benefiting Qi was highly supported.Conclusion:On the foundation of association rules and cluster analysis,the treatment of delayed diarrhea induced by irinotecan adopts herbs of invigorating Qi and spleen,combined with the ones of inducing diuresis to alleviate edema,the ones of clearing heat and drying dampness,the ones of warming the middle energizer,the ones of constricting and consolidating.

关 键 词：腹泻 迟发性 伊立替康 中药 用药规律 关联规则 系统聚类 

分 类 号：R256.34[医药卫生—中医内科学]