P13K/AKT/mTOR信号通路在椎间盘退变中的相关作用机制研究进展  

Research Progress on P13K/AKT/mTOR Signaling Pathway in Intervertebral Disc Degeneration

作　　者：孙凤歧[1] 温少瑾[1] 范有福[1] 雒永生[1] SUN Fengqi;WEN Shaojin;FAN Youfu;LUO Yongsheng(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050

出　　处：《西部中医药》2025年第4期106-110,共5页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省自然科学基金(22JR5RA623);2022兰州市科技计划项目(2022-5-96)。

摘　　要：磷脂酰肌醇三羟基激酶/蛋白激酶B/雷帕霉素靶蛋白(phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin,P13K/AKT/mTOR)信号通路是椎间盘退变(intervertebral disc degeneration,IDD)中重要的信号通路之一,并与髓核细胞功能和代谢有着密切关系,在IDD的发生和发展中起着重要作用。现对IDD中的P13K/AKT/mTOR信号通路及其相关中医药作用展开论述,总结P13K/AKT/mTOR通路在IDD中的相关作用机制,并综述以该通路为靶点的中医药研究进展,以期阐明中医药干预P13K/AKT/mTOR信号通路对IDD的作用机制,为中医药治疗IDD提供新思路和新方法。Phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin(P13K/AKT/mTOR)signaling pathway,one of the important signaling pathways of intervertebral disc degeneration(IDD),is closely related to the function and metabolism of nucleus cells,playing an vital role in the incidence and development of IDD.The article stated P13K/AKT/mTOR signaling pathway in IDD and the relevant TCM effects by summarizing the relevant mechanism of P13K/AKT/mTOR signaling pathway in IDD,and research progress of TCM with the pathway as the targets,so as to illustrate the mechanism of TCM intervention on IDD via P13K/AKT/mTOR signaling pathway,which could provide new thinking and ideas for TCM therapy of IDD.

关 键 词：椎间盘退变 P13K/AKT/mTOR信号通路 髓核细胞 中药 

分 类 号：R274.9[医药卫生—中西医结合]