二至天癸方联合分期针灸对体外受精-胚胎移植女性妊娠率的影响  

Clinical Observation on the Improvements of Pregnancy Rate in Women Undergoing IVF-ET by Erzhi Tiangui Prescription Combined with Staged Acupuncture

作　　者：张芳芳 孙梦 田丽颖 ZHANG Fangfang;SUN Meng;TIAN Liying(Anhui University of Chinese Medicine,Hefei 230031,China;The Second Affiliated Hospital of Anhui University of Chinese Medicine/Anhui Acupuncture and Moxibustion Hospital,Hefei 230061,China)

机构地区：[1]安徽中医药大学,安徽合肥230031 [2]安徽中医药大学第二附属医院/安徽省针灸医院,安徽合肥230061

出　　处：《西部中医药》2025年第4期153-156,共4页Western Journal of Traditional Chinese Medicine

基　　金：田丽颖全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号)。

摘　　要：目的:探讨二至天癸方联合分期针灸提高体外受精-胚胎移植(in vitro fertilizationembryo transfer,IVF-ET)女性妊娠率的效果。方法:回顾性选取91例行IVF-ET的不孕症患者的临床资料,根据治疗方法分为对照组(55例)和联合组(36例)。对照组患者采用分期针灸治疗,联合组采用二至天癸方联合分期针灸治疗。比较两组患者治疗后妊娠结局、治疗前后症状评分、雌二醇(estradiol,E2)、孕酮(progesterone,P)、卵泡刺激素(follicle stimulating hormone,FSH)、子宫内膜容受性[子宫内膜厚度、阻力指数(resistance index,RI)、搏动指数(pulsation index,PI)],以及治疗期间安全性情况。结果:治疗后与对照组比较,联合组生化妊娠率更低,临床妊娠率更高(P<0.05);治疗后两组症状评分均降低,且与对照组比较,联合组更低(P<0.05);治疗后两组E2、P、FSH水平均升高,且与对照组比较,联合组更高(P<0.05);治疗后两组子宫内膜容受性指标均改善,且与对照组比较,联合组子宫内膜容受性指标更优(P<0.05);治疗期间,两组副作用发生率比较,差异无统计学意义(P<0.05)。结论:二至天癸方联合分期针灸治疗行IVF-ET的不孕症患者,可以改善妊娠结局、性激素及子宫内膜容受性,减轻临床症状,且安全性好。Objective:To discuss the effects of Erzhi Tiangui prescription and staged acupuncture on the improvement of pregnancy rate in women undergoing in vitro fertilization-embryo transfer(IVF-ET).Methods:Clinical data of 91 infertile patients undergoing IVF-ET were retrospectively chosen,and they were divided into the control group(55 cases)and the combination group(36 cases)according to therapeutic methods.The control group adopted staged acupuncture,Erzhi Tiangui prescription and staged acupuncture were administered to the combination group.To compare pregnancy outcome after the treatment,symptom scores before and after the treatment,the levels of E2,P and FSH,endometrial receptivity(endometrial thickness,RI and PI)and the safety during therapeutic period between both groups.Results:After the treatment,compared with the control group,the rate of biochemical pregnancy was lower while clinical pregnancy rate was higher in the combination group(P<0.05);after the treatment,symptom scores were reduced in the two groups,and compared with the control group,the combination group was lower(P<0.05);after the treatment,the levels of E2,P and FSH were elevated in the two groups,and compared with the control group,the combination group was higher(P<0.05);after the treatment,the indexes of endometrial receptivity were improved,and compared with the control group,the indexes of the combination group were better(P<0.05);during therapeutic period,the difference had no statistical meaning in the incidences of adverse reactions between the two groups(P>0.05).Conclusion:Erzhi Tiangui prescription and staged acupuncture in the treatment of infertile patients undergoing IVF-ET could improve the outcome of pregnancy,sex hormone and endometrial receptivity,relieve clinical symptoms with good safety.

关 键 词：体外受精-胚胎移植 不孕症 二至天癸方 分期针灸 女性 妊娠率 

分 类 号：R271.41[医药卫生—中医妇科学]