基于Citespace中医药调控足细胞的可视化分析  

Visual analysis of traditional Chinese medicine regulation of podocytes based on Citespace

作　　者：李俐鸳 谢璇 LI Liyuan;XIE Xuan(Second Clinical School of Beijing University of Traditional Chinese Medicine/Department of Dongfang Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学第二临床医学院/北京中医药大学东方医院,北京100078

出　　处：《四川中医》2025年第4期174-182,共9页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:基于CiteSpace软件分析近10年中医药调控足细胞的研究现状、热点及趋势,为后续相关研究提供参考。方法:计算机检索中国知网近10年关于中医药调控足细胞的相关研究文献。采用CiteSpace6.3.R1软件统计年度发文量,并对核心作者、机构及关键词等内容进行可视化分析,利用图谱对中医药调控足细胞的发展趋势及研究热点进行分析。结果:纳入文献615篇,国内发文量总体呈波动上升趋势。作者合作团队以高彦彬、王悦芬、陈志强、檀金川、喻嵘等为主。发文较多的研究机构包括南京中医药大学、北京中医药大学、浙江中医药大学等。文献关键词形成的9个聚类显示该领域研究热点主要集中于自噬、信号通路、凋亡、高糖、糖肾宁、蛋白尿、氧化应激等。文献中研究较多的疾病为糖尿病肾病(DKD)和膜性肾病(MN)。结论:中医药调控足细胞领域相关研究近年热度较高。机制研究为该领域研究热点,主要围绕自噬、凋亡、炎症反应、氧化应激、上皮间充质转分化等方面。对足细胞损伤新靶点的识别、开展足细胞特异性药物的临床试验以及对足细胞靶向药物输送系统的开发是未来的研究趋势。Objective:To analyze the research status,hotspots,and trends of traditional Chinese medicine regulation of podocytes in the past 10years based on CiteSpace software,and provide reference for subsequent related research.Method:Com-puter retrieval of relevant research literature on the regulation of podocytes by traditional Chinese medicine in China National Knowledge Infrastructure(CNKI)in the past 10years.CiteSpace6.3.R1software was used to calculate the annual publication volume,and visual analysis was conducted on core authors,institutions,and keywords.A graph was used to analyze the develop-ment trend and research hotspots of traditional Chinese medicine regulation of podocytes.Results:615articles were included,and the overall number of domestic publications showed a fluctuating upward trend.The author's collaborative team is mainly composed of Gao Yanbin,Wang Yuefen,Chen Zhiqiang,Tan Jinchuan,Yu Rong,and others.Research institutions that have published numerous articles include Nanjing University of Traditional Chinese Medicine,Beijing University of Traditional Chinese Medicine,Zhejiang University of Traditional Chinese Medicine,etc.The nine clusters formed by literature keywords show that the research hotspots in this field mainly focus on autophagy,signaling pathways,apoptosis,high glucose,diabetic nephropathy,proteinuria,oxidative stress,etc.The diseases studied more in the literature are diabetes nephropathy(DKD)and membranous nephropathy(MN).Conclusion:Research on the regulation of podocytes by traditional Chinese medicine has been highly popular in recent years.Mechanism research is a hot topic in this field,mainly focusing on autophagy,apoptosis,inflammatory response,oxidative stress,epithelial mesenchymal transition,and other aspects.The identification of new targets for podocyte injury,clinical trials of podocyte specific drugs,and the development of podocyte targeted drug delivery systems are future research trends.

关 键 词：中医药 足细胞 可视化分析 知识图谱 CITESPACE 

分 类 号：R285[医药卫生—中药学]