痛泻要方治疗大肠相关性疾病的研究进展  

Researchprogress on Tongxie Yaofang for the treatment of large intestine-related diseases

作　　者：李晶晶 邓修洪 杨霞[1] 陈敏[2] LI Jingjing;DENG Xi-uhong;YANG Xia(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)

机构地区：[1]成都中医药大学附属医院,四川成都610072 [2]成都中医药大学附属医院/临床医学院,四川成都610072

出　　处：《四川中医》2025年第4期214-221,共8页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家自然基金科学委员会面上项目(编号:82274529);科研能力提升“百人计划”项目(编号:20-B05)。

摘　　要：痛泻要方是临床治疗肝郁脾虚型腹痛、泄泻的常用方剂,目前应用以消化系统疾病为主。前期回顾研究表明,痛泻要方可通过多途径、多靶点、多通道等机制来发挥抗炎、抗肿瘤、调节免疫、降低内脏敏感性等作用,其治疗肠易激综合征、功能性腹泻、溃疡性结肠炎、结直肠肿瘤、放射性肠炎等大肠相关性疾病的临床疗效确切,其治疗上述疾病的价值值得被进一步挖掘和利用。笔者通过相关文献的检索与整理,总结了痛泻要方治疗大肠相关性疾病的理论依据、临床研究及作用机制,以期为痛泻要方进一步提高防治大肠相关性疾病及其作用机制的深入研究提供参考依据。Tongxie Yaofang is a commonly used formula for the clinical treatment of abdominal pain and diarrhea caused by liver depression and spleen deficiency,and its current application focuses on digestive system diseases.Previous studies have shown that Tongxie Yaofang can play the roles of anti-inflammation,anti-tumor,immunity regulation,and reduction of visceral sensitivity through multi-pathway,multi-target and multi-channel mechanisms,and its clinical efficacy in the treatment of large intestine-related diseases(e.g.,irritable bowel syndrome,functional diarrhea,ulcerative colitis,colorectal tumors,and radio-lucent enteritis,etc.)has been confirmed.Its value in treating the above diseases is worth further exploration and utilization.Through the search and collation of related literature,the review summarizes the theoretical basis,clinical research and mecha-nisms of Tongxie Yaofang for the treatment of large intestine-related diseases,which is expected to serve as a reference for the further research on Tongxie Yaofang in the prevention and treatment of large intestine-related diseases and the mechanisms.

关 键 词：痛泻要方 肠易激综合征 溃疡性结肠炎 结直肠肿瘤 

分 类 号：R256.3[医药卫生—中医内科学]