雷公藤在心血管系统中的调控作用及机制研究进展  

Research progress on the regulatory role and mechanism of Tripterygium wilfordii Hook.f.in the cardiovascular system

作　　者：李嘉铮 韩梅 盛硕 孙家政 刘宏生[3] LI Jiazheng;HAN Mei;SHENG Shuo;SUN Jiazheng;LIU Hongsheng(Clinical Medical college,Jining Medical University,Jining 272013,China;The Second Affiliated Hospital of Shandong First Medical University,Tai'an 271000,China;Department of Cardiac Intensive Medicine,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272013 [2]山东第一医科大学第二附属医院,山东泰安271000 [3]济宁医学院附属医院心脏重症医学科,山东济宁272029

出　　处：《老年医学研究》2025年第2期86-89,共4页Geriatrics Research

基　　金：济宁市重点研发计划项目(2023YXNS155,TWEAK/Fn14在缺氧性肺动脉高压中的表达及意义)。

摘　　要：现代研究发现,雷公藤具有抗炎、抗氧化应激、抗血栓形成、抑制血管平滑肌细胞异常增殖、调节脂质代谢、改善心肌纤维化及减轻血管重构等多重作用,在心血管系统疾病中展现出多靶点干预潜力。本文综述雷公藤及其活性成分抑制动脉粥样硬化斑块形成、改善心肌缺血损伤、延缓血管重构进程等内容,系统阐明其多维度调控机制,以期为雷公藤在心血管疾病的临床应用和深入研究提供理论支持。Recent research has unveiled the diverse effects of Tripterygium wilfordii Hook.f.,including anti-inflam-matory,anti-oxidative stress,anti-thrombotic,anti-proliferative actions on vascular smooth muscle cells,lipid metabolism regulation,myocardial fibrosis improvement,and vascular remodeling alleviation.These findings underscore its potential for multi-target intervention in cardiovascular diseases.This review examines the inhibitory effects of Tripterygium wil-fordii Hook.f.and its active constituents on atherosclerotic plaque formation,myocardial ischemic injury improvement,and vascular remodeling delay,elucidating its comprehensive regulatory mechanisms.The aim is to offer theoretical under-pinning for the clinical application and further exploration of Tripterygium wilfordii Hook.f.in cardiovascular diseases.

关 键 词：雷公藤 雷公藤甲素 雷公藤红素 心血管疾病 动脉粥样硬化 心肌缺血 血管重构 

分 类 号：R54[医药卫生—心血管疾病]