2型糖尿病合并代谢综合征患者血清SFRP5、sICAM-1、Fetuin-B水平及临床意义  

Levels of serum SFRP5,sICAM-1 and Fetuin-B in patients with type 2 diabetes mellitus complicated with metabolic syndrome and their clinical significance

作　　者：徐丽丹 刘瑜 赵洪影 XU Lidan;LIU Yu;ZHAO Hongying(Department of Internal Medicine,Jiamusi Hospital of Infectious Diseases,Jiamusi,Heilongjiang 154002,China;Department of Integrative Medicine,Jiamusi Infectious Disease Hospital,Jiamusi,Heilongjiang 154002,China;Department of Endocrinology,Jiamusi Central Hospital,Jiamusi,Heilongjiang 154002,China)

机构地区：[1]佳木斯市传染病院内科,黑龙江佳木斯154002 [2]佳木斯市传染病院中西医结合科,黑龙江佳木斯154002 [3]佳木斯市中心医院内分泌科,黑龙江佳木斯154002

出　　处：《国际检验医学杂志》2025年第9期1030-1034,1040,共6页International Journal of Laboratory Medicine

基　　金：黑龙江省卫生计生委科研课题项目(2018099)。

摘　　要：目的探究2型糖尿病(T2DM)合并代谢综合征(MS)患者血清分泌型卷曲相关蛋白5(SFRP5)、可溶性细胞间黏附分子-1(s ICAM-1)、胎球蛋白B(Fetuin-B)水平及临床意义。方法选取2021年4月至2023年4月佳木斯市传染病院收治的142例T2DM患者作为研究对象,根据T2DM患者是否合并MS将其分为MS组(n=75)和非MS组(n=67)。采用酶联免疫吸附试验(ELISA)测定血清SFRP5、s ICAM-1、Fetuin-B水平,采用多因素Logistic回归分析确定T2DM患者合并MS的影响因素,SFRP5、s ICAM-1、Fetuin-B对T2DM患者合并MS的诊断效能建立受试者工作特征(ROC)曲线分析。结果MS组与非MS组的HDL-C、HOMA-IR比较,差异有统计学意义(P<0.05)。与非MS组相比,MS组血清SFRP5水平显著降低(P<0.05),s ICAM-1、Fetuin-B水平显著升高(P<0.05)。多因素Logistic回归分析显示,SFRP5、HDL-C是影响T2DM患者合并MS的保护因素(P<0.05),s ICAM-1、Fetuin-B、HOMA-IR是影响T2DM患者合并MS的危险因素(P<0.05)。血清SFRP5、s ICAM-1、Fetuin-B三者联合诊断T2DM患者合并MS的曲线下面积最大,其评估效能显著优于血清SFRP5、s ICAM-1、Fetuin-B各单独诊断(Z_(三者联合-SFRP5)=2.466、P=0.014,Z_(三者联合-s ICAM-1)=3.550、P<0.001,Z_(三者联合-Fetuin-B)=3.697、P<0.001)。结论T2DM合并MS患者血清SFRP5水平降低,s ICAM-1、Fetuin-B水平升高,三者联合诊断T2DM患者合并MS具有较好的效果。Objective To investigate the levels and clinical significance of serum secreted frizzled related protein 5(SFRP5),soluble cell adhesion molecule-1(sI CAM-1),and Fetuin-B in patients with type 2 diabetes mellitus(T2DM)complicated with metabolic syndrome(MS).Methods A total of 142 T2DM patients admitted in the Jiamusi Hospital of Infectious Diseases from April 2021 to April 2023 were selected as the study subjects.T2DM patients were grouped into MS group(n=75)and non MS group(n=67)based on whether they had MS.Enzyme linked immunosorbent assay(ELISA)was applied to determine the expression levels of serum SFRP5,sI CAM-1,and Fetuin-B.Logistic regression was applied to analyze and determine the influencing factors of complicated MS in T2DM patients.The diagnostic efficacy of SFRP5,sI CAM-1,and Fetuin-B in T2DM patients with MS was analyzed by establishing receiver operating characteristic(ROC)curve.Results There were statistically significant differences in HDL-C and HOMA-IR between the MS group and the non MS group(P<0.05).Compared with the non MS group,the serum SFRP5 level in the MS group decreased(P<0.05),while the sI CAM-1 and Fetuin-B levels increased(P<0.05).Logistic regression analysis showed that SFRP5 and HDL-C were protective factors for the development of MS in T2DM patients(P<0.05),while sI CAM-1,Fetuin-B,and HOMA-IR were risk factors for the development of MS in T2DM patients(P<0.05).The combination of serum SFRP5,sI CAM-1 and Fetuin-B had the largest area under the curve in diagnosing MS in T2DM patients,and its evaluation efficacy was obviously better than that of the individual diagnosis of serum SFRP5,sI CAM-1,and Fetuin-B(Z_(combination-SFRP5)=2.466,P=0.014,Z_(combination-SICAM-1)=3.550,P<0.001,Z_(combination-Fetuin-B)=3.697,P<0.001).Conclusion The serum SFRP5 level in patients with T2DM complicated with MS decreases,while sI CAM-1 and Fetuin-B levels increase.The combination of the three has a good effect in diagnosing complicated MS in T2DM patients.

关 键 词：2型糖尿病 代谢综合征 分泌型卷曲相关蛋白5 可溶性细胞间黏附分子-1 胎球蛋白B 

分 类 号：R587.1[医药卫生—内分泌] R589[医药卫生—内科学]