孕期体重指数、尿蛋白和s TWEAK水平与子痫前期严重程度及妊娠结局的相关性  

Correlation of body mass index,urinary protein and s TWEAK levels during pregnancy with the severity of preeclampsia and pregnancy outcome

作　　者：徐三会 赵岩 王轲 解玲玲 XU Sanhui;ZHAO Yan;WANG Ke;XIE Lingling(Department of Clinical Laboratory,Xingtai People′s Hospital,Xingtai,Hebei 054000,China;Department of Stomatology,Xingtai People′s Hospital,Xingtai,Hebei 054000,China;Physical Examination Center,Xingtai People′s Hospital,Xingtai,Hebei 054000,China;Xingtai Maternal and Child Health Hospital,Xingtai,Hebei 054099,China)

机构地区：[1]邢台市人民医院检验科,河北邢台054000 [2]邢台市人民医院口腔科,河北邢台054000 [3]邢台市人民医院体检中心,河北邢台054000 [4]邢台市妇幼保健院,河北邢台054099

出　　处：《国际检验医学杂志》2025年第9期1077-1081,共5页International Journal of Laboratory Medicine

基　　金：2024年邢台市市级科技计划项目(2024ZC183)。

摘　　要：目的 探究孕期体重指数、尿蛋白和肿瘤坏死因子样凋亡微弱诱导剂(s TWEAK)水平与子痫前期严重程度及妊娠结局的相关性。方法 选取2022年4月至2023年4月期间在邢台市人民医院进行产检的63例子痫前期患者,其中33例轻度子痫前期患者纳入轻度组,30例重度子痫前期患者纳入重度组,对组间体格特征、尿蛋白及s TWEAK水平进行记录,并对患者进行追踪随访,探究其与妊娠结局的相关性。结果 轻度组患者的收缩压、舒张压低于重度组,血浆白蛋白高于重度组(P<0.05),轻度组和重度组患者的孕前体重、孕前体重指数比较,差异无统计学意义(P>0.05),轻度组分娩体重及孕期体重增加量均低于重度组(P<0.05),轻度组患者的24 h尿蛋白定量低于重度组,s TWEAK表达水平高于重度组(P<0.05),良好妊娠结局组患者的孕前体重、孕前体重指数、分娩体重及孕期体重增加量均低于不良妊娠结局组(P<0.05),良好妊娠结局组患者的24 h尿蛋白定量低于不良妊娠结局组,s TWEAK表达水平高于不良妊娠结局组(P<0.05),经受试者工作特征(ROC)曲线分析,孕前体重指数、孕前体重、分娩体重、孕期体重增加量、24 h尿蛋白定量、s TWEAK水平对患者不良妊娠结局的预测曲线下面积(AUC)分别为0.906、0.690、0.919、0.664、0.908、0.793,孕前体重指数、分娩体重、24 h尿蛋白定量、s TWEAK水平联合预测患者不良妊娠结局的预测AUC为0.932。结论 孕期体重指数、尿蛋白和s TWEAK水平与子痫前期的严重程度和妊娠结局密切相关,这些指标可能有助于早期识别高风险孕妇,从而采取适当的干预措施,改善妊娠结局。Objective To explore the correlation of body mass index,urinary protein and tumor necrosis factor-like weak inducer of apoptosis(s TWEAK) during pregnancy with the severity of preeclampsia and pregnancy outcome.Methods A total of 63 patients with preeclampsia who were examined in Xingtai People's Hospital from April 2022 to April 2023 were enrolled in the study,33 patients with mild preeclampsia were included in the mild group and 30 patients with severe preeclampsia were included in the severe group.Physical characteristics,urinary protein and s TWEAK levels between the groups were recorded,and the patients were followed up to explore the correlation with pregnancy outcome.Results The systolic and diastolic blood pressure of patients in the mild group were lower than those in the severe group,and the plasma albumin was higher than that in the severe group(P<0.05).There was no statistically significant difference in pre pregnancy weight and pre pregnancy body mass index between the mild and severe groups of patients(P>0.05).The delivery weight and weight gain during pregnancy in the mild group were lower than those in the severe group(P<0.05).The 24-hour urinary protein quantification in the mild group was lower than that in the severe group,and the s TWEAK expression level was higher than that in the severe group(P<0.05).The pre pregnancy weight,pre pregnancy body mass index,delivery weight,and weight gain during pregnancy in the good pregnancy outcome group were all lower than those in the adverse pregnancy outcome group(P<0.05).The 24-hour urinary protein quantification in the good pregnancy outcome group was lower than that in the adverse pregnancy outcome group,and the s TWEAK expression level was higher than that in the adverse pregnancy outcome group(P<0.05).Receiver operating characteristic(ROC) curve analysis revealed that the area under the curve(AUC) of pre pregnancy body mass index,pre pregnancy weight,delivery weight,gestational weight gain,24-hour urinary protein quantification,and s TWEAK expressio

关 键 词：孕期体重指数 尿蛋白 肿瘤坏死因子样凋亡微弱诱导剂 子痫 妊娠结局 

分 类 号：R714.245[医药卫生—妇产科学]