巨噬细胞与肿瘤铁死亡的研究进展  

Research progress on macrophages and tumor ferroptosis

作　　者：刘芳[1] 樊婷婷 马晓霞[1] 刘青林(综述) 陈彻(审校)[1] LIU Fang;FAN Tingting;MA Xiaoxia;LIU Qinglin;CHEN Che(Gansu University of Chinese Medicine,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000

出　　处：《国际检验医学杂志》2025年第9期1121-1125,共5页International Journal of Laboratory Medicine

基　　金：甘肃省科技计划项目(22JR11RA124);兰州市科技计划项目(2023-2-12);甘肃中医药大学科学研究与创新基金项目(2022KCYB-2);甘肃中医药大学学生科技学术创新基金项目(xskj-202580、xskj-202582)。

摘　　要：巨噬细胞与肿瘤进展密切相关,既可以通过促进炎症、血管生成和免疫抑制等方式促进肿瘤的生长和扩散,也可以通过直接杀伤肿瘤细胞与引发特异性免疫应答等方式对肿瘤产生杀伤作用。铁死亡作为一种铁依赖性的脂质过氧化导致的细胞死亡方式,从铁稳态的角度调控可以有效地杀死肿瘤细胞,也可以释放促炎因子,引发炎症反应,改变肿瘤的生存环境以及降低肿瘤细胞的免疫易感性。近年来,越来越多的研究表明巨噬细胞与铁死亡存在密切关联。该文主要从巨噬细胞与铁死亡的功能特性及靶向治疗肿瘤方面介绍两者的影响关系,并从巨噬细胞两种分化表型的功能特性对治疗肿瘤铁死亡作一综述。Macrophages are closely related to tumor progression,and can promote tumor growth and proliferation by promoting inflammation,angiogenesis and immunosuppression and so on,as well as killing tumors by directly killing tumor cells and triggering specific immune responses.Iron death,as an iron-dependent cell death caused by lipid peroxidation,can effectively kill tumor cells when regulated from the perspective of iron homeostasis,and can also release pro-inflammatory factors,trigger inflammatory reactions,change the survival environment of tumors as well as reduce the immune susceptibility of tumor cells.In recent years,more and more studies have shown that macrophages and iron death are closely related.In this paper,the relationship between macrophages and iron death in terms of their functional properties and targeting of tumors are mainly introduced,and an overview of the functional properties of the two differentiated phenotypes of macrophages for the treatment of iron death in tumors is provided.

关 键 词：巨噬细胞 肿瘤 肿瘤微环境 铁死亡 铁代谢 

分 类 号：R392.12[医药卫生—免疫学]