环糊精及其衍生物作为纳米药物载体的研究进展  

Research Progress on Cyclodextrin and Its Derivatives as Nano-drug Carriers

作　　者：熊小燕 林绮欣 吴斌华 朱旭峰 XIONG Xiaoyan;LIN Qixin;WU Binhua;ZHU Xufeng(Guangzhou Institute of Chemistry,Chinese Academy of Sciences,Guangzhou 510650,China;University of Chinese Academy of Sciences,Beijing 100049,China;CAS Testing Technical Services(Guangzhou)Co Ltd,Guangzhou 510650,China;School of Ocean and Tropical Medicine,Guangdong Medical University,Zhanjiang 524023,China)

机构地区：[1]中国科学院广州化学研究所,广州510650 [2]中国科学院大学,北京100049 [3]中科检测技术服务(广州)股份有限公司,广州510650 [4]广东医科大学海洋与热带医学学院,湛江524023

出　　处：《河北师范大学学报(自然科学版)》2025年第3期276-286,共11页Journal of Hebei Normal University:Natural Science

基　　金：广东省科技创新战略专项资金竞争性分配项目(2023A011004)。

摘　　要：环糊精聚合物因其具有尺寸小、价格适宜、性质稳定的特点而在纳米药物载体研究领域备受关注,其作为纳米靶向药物载体可提高药物的生物相容性,保护脂溶性药物.围绕环糊精聚合物作为纳米药物载体,展开论述了常见药物载体类型(纳米微球、纳米脂质体、聚合物胶束、磁性纳米粒子、金属有机框架和水凝胶)目前国内外研究进展以及实际应用情况.Cyclodextrin polymers have attracted much attention in the field of nano-drug carrier research,due to their small size,affordable price and stable properties.As nano-targeted drug carriers,cyclodextrin polymers can promote drug biocompatibility and protect lipophilic drugs.This article mainly focused on cyclodextrin polymers as nano-drug carriers,and elaborated on the common types of drug carriers(nanospheres,nanoliposomes,polymer micelles,magnetic nanoparticles,metal-organic frameworks and hydrogels),as well as their current research progress and practical applications both domestically and internationally.

关 键 词：纳米药物 环糊精 药物载体 自组装 

分 类 号：O636.1[理学—高分子化学]