枸地氯雷他定片对嗜酸性粒细胞肺炎患者肺功能及相关指标的影响  

Effect of Desloratadine Citrate Disodium Tablets on Lung Function and Related Indicators in Patients with Eosinophilic Pneumonia

作　　者：张文静 Zhang Wenjing(Department of Respiratory and Critical Care Medicine,Puyang People’s Hospital,Puyang,Henan,457000,China)

机构地区：[1]濮阳市人民医院呼吸与重症医学科,河南濮阳457000

出　　处：《黑龙江医学》2025年第9期1087-1089,共3页Heilongjiang Medical Journal

摘　　要：目的:分析枸地氯雷他定片辅助治疗嗜酸性粒细胞肺炎(CEP)患者的效果及对疾病相关指标的影响。方法:回顾性分析2019年2月—2022年11月濮阳市人民医院收治的70例CEP患者资料,根据治疗方案分为参照组(采用布地奈德治疗,35例)和研究组(基于参照组加用枸地氯雷他定片治疗,35例)。治疗2周后,比较两组患者疗效、不良反应、治疗前后临床症状消失时间、肺功能[用力肺活量(FVC)、潮气量(TV)、第1 s用力呼吸容积(FEV1)、呼气峰流速(PEF)]、疾病相关指标[血沉(ESR)、降钙素原(PCT)、C反应蛋白(CRP)、嗜酸性粒细胞细胞数(EOS)]。结果:研究组患者总有效率高于参照组,差异有统计学意义(χ^(2)=4.590,P<0.05);治疗后,研究组患者咳嗽、咳痰、气促、肺部啰音、发热等症状消失时间均快于参照组,差异均有统计学意义(t=9.899、10.046、4.103、7.361、10.721,P<0.001);治疗后,研究组患者FVC、TV、FEV1、PEF升高幅度均大于参照组,差异均有统计学意义(t=6.407、3.714、3.346、4.949,P<0.05);治疗后,研究组患者ESR、PCT、CRP、EOS均低于参照组,差异均有统计学意义(t=8.330、6.998、10.379、2.673,P<0.05)。结论:枸地氯雷他定片辅助治疗CEP疗效确切,能减轻患者炎症反应,改善患者肺功能及临床症状,安全可靠。Objective:To analyze the effect of adjunctive treatment with desloratadine citrate disodium tablets on eosinophilic pneumonia(CEP)patients and its impact on disease-related indicators.Methods:Data of 70 patients with CEP admitted to Puyang People’s Hospital from February 2019 to November 2022 were retrospectively analyzed.According to the treatment plan,they were divided into the reference group(35 cases were treated with budesonide)and the study group(35 cases were treated with desloratadine citrate tablets based on the reference group).After 2 weeks of treatment,the efficacy and adverse reactions of the two groups were compared,as well as the disappearance time of clinical symptoms before and after treatment,lung function[forced vital capacity(FVC),tidal volume(TV),forced expiratory volume in 1 second(FEV1),peak expiratory flow rate(PEF)],disease-related indicators[erythrocyte sedimentation rate(ESR),procalcitonin(PCT),C-reactive protein(CRP),eosinophil count(EOS)].Results:The total effective rate of the study group was significantly higher than that of the reference group(χ^(2)=4.590,P<0.05).After treatment,symptoms,such as cough,expectoration,shortness of breath,pulmonary rales and fever disappeared faster in the study group than in the reference group,with statistically significant difference(t=9.899,10.046,4.103,7.361,10.721;P<0.05).After treatment,the increases of FVC,TV,FEV1 and PEF in the study group were higher than those in the reference group,and the differences were statistically significant(t=6.407,3.714,3.346,4.949;P<0.05).After treatment,ESR,PCT,CRP and EOS in the study group were lower than those in the reference group,with statistically significant difference(t=8.330,6.998,10.379,2.673;P<0.05).Conclusion:The adjunctive treatment of CEP with desloratadine citrate disodium tablets is effective.It can reduce inflammatory reactions,improve lung function and clinical symptoms.It is safe and reliable.

关 键 词：嗜酸性粒细胞肺炎 枸地氯雷他定片 疗效 肺功能 

分 类 号：R563.1[医药卫生—呼吸系统]